|Molecular Formula||C10H10ClN5O5PS · Na|
|Description||Sp-8-Cl-cAMPS is a resistant stimulator of protein kinase A, the cAMP agonist. Compared with 8-Cl-cAMP, it has the increased lipophilic and membrane-permeant properties.|
|Purity||≥ 99% by HPLC|
|Synonyms||8- Chloroadenosine- 3', 5'- monophosphorothioate, Sp- isomer|
Sp-cAMPS-AM is a precursor of Sp-cAMPS, the PDE-resistant protein kinase A stimulator. Sp-cAMPS is released after metabolism of Sp-cAMPS-AM by esterases.
Sp-6-Phe-cAMPS is a selective and PDE-resistant stimulator of protein kinase A, which is used as an Epac-negative control.
2'-O-Me-cGMP is a polar analogue of cGMP that activate neither protein kinase G nor Epac. It exhibits an inactive effect in patch clamp applications and can be ...
8-Br-c-diGMP is an analogue of c-diGMP, the bacterial second messenger, which can be used for binding studies and precursor for further modifications with space...
Rp-6-Cl-cPuMPS is a PDE-resistant modulator of protein kinase A that can be modified in position 6.
2'd-7-CH-ATP is an isosteric modification of dATP.
8-ADOA-cAMP is a selective and hydrophilic cAMP analogue, which is used as a ligand in affinity chromatography and can be modified with fluorophores.
c-diAMP was recognized as a second messenger for signalling DNA integrity in Bacillus subtilisduring sporulation, and an additional purine-based signalling nucl...
Rp-2'-AEC-cAMPS is an analogue of Rp-cAMPS, the PKA inhibitor, which is used for immobilization as an affinity ligand or for coupling of labelling structures su...
8-Br-2'-O-Me-cAMP is an activator of the exchange protein activated by cAMP (Epac) or cAMP-GEF without affecting protein kinase A.
2',2''-Di-Biotin-16-c-diAMP is an analogue of c-diAMP, the bacterial second messenger. It is a potential tracer in immunoassays and commonly used for affinity c...
2-AHA-cAMP-Agarose is the second messenger cAMP immobilized on agarose by an aminohexylamino spacer, which can be used in affinity chromatography of cyclic nucl...
Sp-6-Cl-cPuMPS is a PDE-resistant activator of protein kinase A that can be modified in position 6.
8-APT-cGMP is an isozyme-selective stimulator of cGMP-dependent protein kinase I a with a prenference for type I a over I by a factor of 200.
2'-O-MB-cAMP is a precursor of cAMP. cAMP and butyrate are released after the metabolism of 2'-O-MB-cAMP by esterases.
Sp-cCMPS is a PDE-resistant cCMP, the potential second messenger, which may activate cCMP-binding proteins.
Sp-2'-AEC-cAMPS is a phosphodiesterase-resistant ligand in affinity chromatography of cAMP and cGMP binding proteins and can be modified with fluorophores and o...
5,6-DCl-cBIMP is a potent activator of protein kinase A, acting on both type I and II. It can be subsequently metabolized by cyclic nucleotide-dependent phospho...