|Molecular Formula||C18H14BrN5O6PS · Na|
|Description||Sp-8-Br-PET-cGMPS is an inhibitor of the retinal type cGMP-gated ion channel (cGMP antagonist) as well as a stimulator of cyclic GMP-dependent protein kinase I α and I ß (cGMP agonist), which is used for distinction between kinase and ion channel mediated effects. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases.|
|Purity||≥ 99% by HPLC|
|Synonyms||8- Bromo- β- phenyl- 1, N2- ethenoguanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt|
8-N3-cAMP is an analogue of cAMP binding proteins used for photoaffinity labelling.
8-AET-cAMP is a ligand for affinity chromatography of cAMP and cGMP binding proteins. It is often modified with fluorophores or other markers.
8-ADOA-cAMP is a selective and hydrophilic cAMP analogue, which is used as a ligand in affinity chromatography and can be modified with fluorophores.
Sp-8-BnT-2'-O-Me-cAMPS is the most potent 2'-substituted activator of Epac2. In human osteosarcoma U2OS cell lines expressing Epac1 or Epac2, Sp-8-BnT-2'-O-Me-c...
c[A(2',5')pS[Sp]-A(3',5')pS[Rp]] is asyntheticdi-thiophosphate analogue of c[A(2',5')pA(3',5')p] with higher stability resisting degradation by phosphodiesteras...
2'-AEC-cGMP-Agarose is the protein kinase G activator cGMP immobilized on agarose by an aminoethylcarbamoyl spacer, which can be used in affinity chromatography...
c-di-2'-d-2''-O-Me-AMP is an analogue of c-diAMP, the bacterial second messenger.
Sp-6-Phe-cAMPS is a selective and PDE-resistant stimulator of protein kinase A, which is used as an Epac-negative control.
8-Br-PET-cGMP is a stimulator of isozymes I α and I β of cGMP-dependent protein kinase, which is used as an excellent cyclic nucleotide muscle relaxants.
2'-AHC-cGMP-Agarose is the protein kinase G activator cGMP immobilized on agarose by an aminohexylcarbamoyl spacer which can be used in affinity chromatography ...
Rp-2'-AHC-cGMPS-Agarose is the PDE-resistant PKG inhibitor Rp-cGMPS immobilized on agarose by an aminohexylcarbamoyl spacer, which can be used in affinity chrom...
cCMP-AM is a membrane-permeant and metabolically activatable prodrug of cCMP, the potential further second messenger. cCMP is released after permeation and meta...
6-Bn-cAMP is a selective stimulator of cAMP-dependent protein kinase which does not activate Epac. Compared to cAMP, it has superior stability against PDE, este...
6-MBC-cAMP is a selective activator of protein kinase A, the cAMP agonist, which has a preference for the A site of cAK II. It can be active to type II in combi...
2'-AHC-cCMP-Agarose is the putative second messenger cCMP immobilized on agarose by an aminoethylcarbamoyl spacer, which can be used in affinity chromatography ...
c-di-2'-dAMP is an analogue of c-diAMP, the bacterial second messenger.