|Molecular Formula||C18H19N5O5PS2 · Na|
|Description||Sp-8-BnT-2'-O-Me-cAMPS is the most potent 2'-substituted activator of Epac2. In human osteosarcoma U2OS cell lines expressing Epac1 or Epac2, Sp-8-BnT-2'-O-Me-cAMPS does not induce Epac signalling at 100 µM possibly for inefficient cellular uptake in this biosystem.|
|Purity||≥ 98% by HPLC|
|Synonyms||8- Benzylthio- 2'- O- methyladenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt|
8-AET-cAMP is a ligand for affinity chromatography of cAMP and cGMP binding proteins. It is often modified with fluorophores or other markers.
Sp-2'-AEC-cAMPS-Agarose is the protein kinase A activator Sp-cAMPS immobilized on agarose by an aminoethylcarbamoyl spacer, which can be used in affinity chroma...
8-Br-cGMP-AM is a precursor of 8-Br-cGMP, the PKG activator. The polar active analogue is released after the metabolism of 8-Br-cGMP-AM by esterases.
8-MA-cAMP is a selective cAMP analogue that has affinity to site B of protein kinase A type I and II. Site A activity is developed when 8-MA-cAMP acts synergist...
6-AH-cAMP-Agarose is the second messenger cAMP immobilized on agarose by an aminohexyl spacer which can be used in affinity chromatography of cyclic nucleotide-...
6-AE-8-N3-cAMP is a photosensitive analogue for photoaffinity labelling. It can be immobilized by the irradiation of UV light. The amino group in position 6 of ...
Rp-2'-AEC-cAMPS is an analogue of Rp-cAMPS, the PKA inhibitor, which is used for immobilization as an affinity ligand or for coupling of labelling structures su...
4-N3-PET-8-Br-cGMP is an analogue used for photoaffinity labelling of cGMP-responsive receptors, and an isozyme-selective activator of cGMP-dependent protein ki...
c[G(2',5')p-2'-dA(3',5')p] is a 2'-deoxy analogue of c[G(2',5')pA(3',5')p], the metazoan cyclic dinucleotide second messenger and STING stimulator, which can be...
Rp-8-AEA-cAMPS is a phosphodiesterase-resistant ligand for affinity chromatography of cAMP and cGMP binding proteins. It is often modified with fluorophores and...
8-N3-6-Biotin-10-cAMP is an analogue in photoaffinity labelling of cAMP binding proteins which can be immobilized by UV light.
c[G(2',5')pA(3',5')p] / 2'3'-cGAMP
c[G(2',5')pA(3',5')p] was considered to be the metazoan second messenger which is produced by cGAMP synthase (cGAS), the mammalian intrinsic immune DNA sensor. ...
8-CPT-cAMP is an activator of cAMP- and cGMP-dependent protein kinase and of Epac. It has an improved membrane permeability, phosphodiesterase stability and sel...
DB-cAMP-AM is a precursor of DB-cAMP. The dibutyryl cAMP is released after the metabolism of DB-cAMP-AM by esterases.
ara-cAMP is an analogue of cAMP, the second messenger. It is commonly used in receptor mapping studies and negative controls.
2'-AHC-cCMP-Agarose is the putative second messenger cCMP immobilized on agarose by an aminoethylcarbamoyl spacer, which can be used in affinity chromatography ...
Rp-8-pCPT-PET-cGMPS is an inhibitor of protein kinase G and probably of retinal cGMP-gated ion channels. It has a resistant against mammalian cyclic nucleotide-...