|Molecular Formula||C10H9ClN4O5PS · Na|
|Description||Sp-6-Cl-cPuMPS is a PDE-resistant activator of protein kinase A that can be modified in position 6.|
|Purity||≥ 98% by HPLC|
|Synonyms||6- Chloropurine riboside- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt|
c[A(2',5')pS[Sp]-A(3',5')pS[Rp]] is asyntheticdi-thiophosphate analogue of c[A(2',5')pA(3',5')p] with higher stability resisting degradation by phosphodiesteras...
8-MABA-cAMP is a fluorescent cAMP analogue (λexc352 nm, λem436 nm).
cCMP-AM is a membrane-permeant and metabolically activatable prodrug of cCMP, the potential further second messenger. cCMP is released after permeation and meta...
2'd-7-CH-ATP is an isosteric modification of dATP.
8-APT-cGMP is an isozyme-selective stimulator of cGMP-dependent protein kinase I a with a prenference for type I a over I by a factor of 200.
Rp,Rp-c-diGMPSS is an analogue of c-diGMP, the bacterial second messenger, with improved stability. It can be used to study ligand-receptor interactions.
c[G(2',5')pA(3',5')p] / 2'3'-cGAMP
c[G(2',5')pA(3',5')p] was considered to be the metazoan second messenger which is produced by cGAMP synthase (cGAS), the mammalian intrinsic immune DNA sensor. ...
Sp-8-OH-cAMPS is a polar analogue of Sp-cAMPS, the protein kinase A activator, with an antagonistic effect of mammalian cyclic nucleotide-dependent phosphodiest...
2',2''-Di-c-didGMP is an analogue of c-diGMP, the bacterial second messenger, which selectively binds the c-diGMP class II riboswitch. It can be used to discrim...
4-N3-PET-8-Br-cGMP is an analogue used for photoaffinity labelling of cGMP-responsive receptors, and an isozyme-selective activator of cGMP-dependent protein ki...
8-Cl-cAMP-AM is a precursor of 8-Cl-cAMP, the PKA activator. The polar active analogue is released after the metabolism of 8-Cl-cAMP-AM by esterases.
EtOH-NH-Agarose is the agarose gel without nucleotide immobilized on it, which can be used as negative control in affinity chromatography experiments.
c[8-AET-G(2',5')pA(3',5')p]-Agarose is the metazoan cyclic dinucleotide second messenger c[G(2',5)pA(3',5')p] immobilized on agarose by an aminoethylthio spacer...
6-AE-cAMP is often used as a ligand for affinity chromatography of cAMP and cGMP binding proteins.
Sp-8-BnT-2'-O-Me-cAMPS is the most potent 2'-substituted activator of Epac2. In human osteosarcoma U2OS cell lines expressing Epac1 or Epac2, Sp-8-BnT-2'-O-Me-c...
6-AE-cAMP-Agarose is the second messenger cAMP immobilized on agarose by an aminoethyl spacer which can be used in affinity chromatography of cyclic nucleotide-...
Rp-8-Br-cAMPS is an analogue of the cAMP with a preference for type I of protein kinase A. Compared to Rp-cAMPS, it has more lipophilic and membrane-permeant pr...
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. It inhibits cell growth, decreases proliferation, increases differentiation and induces apoptos...