Sorafenib tosylate - CAS 284461-73-0
Catalog number:
284461-73-0
Category:
APIs
Molecular Formula:
C21H16ClF3N4O3
Molecular Weight:
464.83
COA:
Inquire
Publictions citing BOC Sciences Products
  • >> More
MSDS:
Inquire
1. Lack of effect of ketoconazole-mediated CYP3A inhibition on sorafenib clinical pharmacokinetics
Chetan Lathia, John Lettieri, Frank Cihon, Martha Gallentine, Martin Radtke, Pavur Sundaresan. Cancer Chemother Pharmacol (2006) 57: 685–692
On day 1 of period 1, all subjects received a single oral dose of sorafenib tosylate 50 mg tablet (calculated as free base sorafenib). After at least a 10-day washout, 400 mg ketoconazole (Nizoral, Janssen Pharmaceutica, Titusville, NJ; Batch 91P0982E) was administered for three consecutive days in period 2. On day 4 in period 2, a single dose of sorafenib tosylate 50 mg tablet (calculated as free base sorafenib) from the same batch as in period 1 was co-administered with 400 mg ketoconazole. Sorafenib doses were administered in the fasted state with 240 ml of water. Ketoconazole was administered for three additional days in period 2 (days 5, 6 and 7) to maintain CYP3A inhibition for the duration of blood sampling. Blood samples (5 ml) for the determination of sorafenib and its metabolite concentrations in plasma were collected before and 0.5, 1, 2, 3, 4, 6, 8, 12, 16, 24, 48, 72, 96, 120, and 168 h after drug administration. Samples were prepared by centrifugation to obtain plasma, which was frozen at -20 ℃ until analysis.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 583840-03-3 Sorafenib-N-oxide

Sorafenib-N-oxide
(CAS: 583840-03-3)

An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of ...

Chemical Structure

CAS 284461-73-0 Sorafenib tosylate

Quick Inquiry

Verification code

Featured Items