Sodium tetraborate decahydrate - CAS 1303-96-4
Molecular Formula:
Molecular Weight:
Sodium tetraborate decahydrate is used as an anti-fungal agent in pharmaceutical formulations.
White Solid
Borax decahydrate; Sodium borate decahydrate
Soluble in water (slightly).
Room Temperature
Melting Point:
1.One-pot labeling-based capillary zone electrophoresis for separation of amino acid mixture and assay of biofluids.
Song L1, Guo Z, Chen Y. Anal Chim Acta. 2011 Oct 10;703(2):257-63. doi: 10.1016/j.aca.2011.07.042. Epub 2011 Aug 3.
A fast, simple and cost-effective one-pot labeling strategy coupled with capillary zone electrophoresis was developed for the complete separation of amino acid mixture. The strategy includes two steps of reactions: Cyanuric chloride was made to react first with 7-amino-1,3-naphthalenedisulfonic acid monopotassium salt at 0 °C for 10 min, and then with amino acids at 55 °C for 6 min. The resulted products, after diluted with water, were injected into capillary zone electrophoresis system for separation. Using a running buffer of 20 mM sodium tetraborate decahydrate at pH 10.1, nineteen amino acids were efficiently separated in 25 min, with relative standard deviation of 0.36-1.6% and 0.96-2.1% (within and between days, respectively) for migration time and 0.030-1.6% and 0.22-2.4% (within and between days, respectively) for peak area. The proposed method has been successfully applied to the determination of free amino acids in biofluids, including human serum, urine, and saliva.
2.In Situ Synthesis of Antimicrobial Silver Nanoparticles within Antifouling Zwitterionic Hydrogels by Catecholic Redox Chemistry for Wound Healing Application.
GhavamiNejad A1, Park CH1, Kim CS1. Biomacromolecules. 2016 Mar 14;17(3):1213-23. doi: 10.1021/acs.biomac.6b00039. Epub 2016 Mar 1.
A multifunctional hydrogel that combines the dual functionality of both antifouling and antimicrobial capacities holds great potential for many bioapplications. Many approaches and different materials have been employed to synthesize such a material. However, a systematic study, including in vitro and in vivo evaluation, on such a material as wound dressings is highly scarce at present. Herein, we report on a new strategy that uses catecholic chemistry to synthesize antimicrobial silver nanoparticles impregnated into antifouling zwitterionic hydrogels. For this purpose, hydrophobic dopamine methacrylamide monomer (DMA) was mixed in an aqueous solution of sodium tetraborate decahydrate and DMA monomer became soluble after increasing pH to 9 due to the complexation between catechol groups and boron. Then, cross-linking polymerization of zwitterionic monomer was carried out with the solution of the protected dopamine monomer to produce a new hydrogel.
3.Inhibition of boric acid and sodium borate on the biological activity of microorganisms in an aerobic biofilter.
Güneş Y1. Environ Technol. 2013 May-Jun;34(9-12):1117-21.
The aim of this work was to study the inhibition effect of boric acid and sodium borate on the treatment of boron containing synthetic wastewater by a down flow aerobic fixed bed biofilm reactor at various chemical oxygen demand (COD)/boron ratios (0.47-20.54). The inhibitory effect of boron on activated sludge was evaluated on the basis of COD removal during the experimental period. The biofilter (effective volume = 2.5 L) was filled with a ring of plastic material inoculated with acclimated activated sludge. The synthetic wastewater composed of glucose, urea, KH2PO4, MgSO4, Fe2 SO4, ZnSO4 x 7H20, KCl, CaCl2, and di-sodium tetraborate decahydrate or boric acid (B = 100-2000 mg L(-1)). The biological treatment of boron containing wastewater resulted in a low treatment removal rate due to the reduced microbial activity as a result of toxic effects of high boron concentrations. The decrease in the COD removal rate by the presence of either boric acid or sodium borate was practically indistinguishable.
4.Optimization and validation of capillary electrophoretic method for the analysis of amphenicols in poultry tissues.
Kowalski P1, Plenis A, Oledzka I. Acta Pol Pharm. 2008 Jan-Feb;65(1):45-50.
A simple, rapid capillary electrophoretic (CE) method for simultaneous analysis of three amphenicols (chloramphenicol, thiamphenicol and florfenicol) in poultry tissues has been developed and validated. The separation condition were: buffer solution composed with 25 mM sodium tetraborate decahydrate and 10 mM sodium dodecylsulfate, an uncoated fused-silica capillary (57 cm x 75 microm i.d.), voltage 20 kV, and temperature 22 degrees C. The method involved simple deproteinization by acetonitrile and SPE extraction procedure. The analytical method was validated according to the FDA bioanalytical method guidance. The method was linear (r > 0.999) at concentrations ranging from: 0.005 - 1 for chloramphenicol, 0.01 - 1 for thiamphenicol, and 0.025 - 5 microg/g for florfenicol. The precision values were less than 9.8 for intra- and 14.8% for inter-day variability, and accuracies ranged from 92.0 to 106.0% for analyzed amphenicols. The overall recoveries of all antibiotics from tissue samples were above 82.
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