Sodium 4-pentynoate - CAS 101917-30-0
Catalog number: 101917-30-0
Category: Inhibitor
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Molecular Formula:
C5H5NaO2
Molecular Weight:
120.08
COA:
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Targets:
Others
Description:
Sodium 4-pentynoate, an alkynylacetate analogue, can be metabolically incorporated onto cellular proteins through biosynthetic mechanisms for profiling of acetylated proteins in diverse cell types.
Purity:
>98%
MSDS:
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InChIKey:
IWIICCMJXWKGSG-UHFFFAOYSA-M
InChI:
InChI=1S/C5H6O2.Na/c1-2-3-4-5(6)7;/h1H,3-4H2,(H,6,7);/q;+1/p-1
Canonical SMILES:
C#CCCC(=O)[O-].[Na+]
1.Bioorthogonal chemical reporters for monitoring protein acetylation.
Yang YY1, Ascano JM, Hang HC. J Am Chem Soc. 2010 Mar 24;132(11):3640-1. doi: 10.1021/ja908871t.
Protein acetylation is a key post-translational modification that regulates diverse biological activities in eukaryotes. Here we report bioorthogonal chemical reporters that enable direct in-gel fluorescent visualization and proteome-wide identification of acetylated proteins via Cu(I)-catalyzed azide-alkyne cycloaddition, often termed "click chemistry". We demonstrate that two alkynyl-acetyl-CoA analogues, 4-pentynoyl-CoA and 5-hexynoyl-CoA, function as efficient substrates of lysine acetyltransferase p300 and serve as sensitive reagents for monitoring p300-catalyzed protein acetylation in vitro. In addition, we demonstrate that three alkynylacetate analogues, sodium 3-butynoate, sodium 4-pentynoate, and sodium 5-hexynoate, can be metabolically incorporated onto cellular proteins through biosynthetic mechanisms for profiling of acetylated proteins in diverse cell types. Mass spectrometry analysis of the enriched 4-pentynoate-labeled proteins revealed many reported as well as new candidate acetylated proteins from Jurkat T cells and specific sites of lysine acetylation.
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CAS 101917-30-0 Sodium 4-pentynoate

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