|Description||Smad3 Inhibitor, SIS 3 is an inhibitor of SMAD3, which is a receptor-regulated intracellular protein that functions downstream of TGF-β as well as activin receptors and mediates their signaling. It plays an important role in cell proliferation, apoptosis, differentiation and formation of extracellular matrix. It is a cell-permeable pyrrolopyridine compound that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling. It has been shown to reduce TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.|
|B0084-310534||25 mg||$299||In stock|
|Solubility||10 mM in DMSO|
|Shelf Life||2 month in rt, long time|
|Boiling Point||721.8±60.0 °C | Condition: Press: 760 Torr|
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Smad3 Inhibitor, SIS3
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