Sitamaquine tosylate - CAS 1019640-33-5
Category: Inhibitor
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Molecular Formula:
C21H33N3O.C7H8O3S
Molecular Weight:
515.71
COA:
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Targets:
Others
Description:
Sitamaquine tosylate is a dose-dependent and orally bioactive inhibitor of complex II (succinate dehydrogenase or SDH) of the respiratory chain in digitonin-permeabilized promastigotes. Sitamaquine has the potential for the treatment of life-threatening visceral leishmaniasis (VL) caused by Leishmania donovani (EC50 value 19.8 μM for L. donovani promastigotes in vitro).
Brife Description:
complex II (succinate dehydrogenase or SDH) inhibitor
Purity:
99%
Related CAS:
57695-04-2 (free base)
Synonyms:
WR6026 tosylate; WR-6026 tosylate; WR 6026 tosylate
MSDS:
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InChIKey:
LOBPWLFCZDGYKW-UHFFFAOYSA-N
InChI:
InChI=1S/C21H33N3O.C7H8O3S/c1-5-24(6-2)14-10-8-7-9-12-22-20-16-18(25-4)15-19-17(3)11-13-23-21(19)20;1-6-2-4-7(5-3-6)11(8,9)10/h11,13,15-16,22H,5-10,12,14H2,1-4H3;2-5H,1H3,(H,8,9,10)
Canonical SMILES:
CCN(CC)CCCCCCNC1=CC(=CC2=C(C=CN=C12)C)OC.CC1=CC=C(C=C1)S(=O)(=O)O
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Chemical Structure

CAS 1019640-33-5 Sitamaquine tosylate

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