|Description||Siramesine hydrochloride is the hydrochloride salt form of Siramesine. Siramesine is a selective sigma-2 receptor agonist with a potent anticancer activity in vivo. It was originally devevloped for treating depressant and it has pro-apoptotic activity on|
|Related CAS||147817-50-3 (Free base)|
|Synonyms||1'-(4-(1-(4-fluorophenyl)-1H-indol-3-yl)butyl)-3H-spiro[isobenzofuran-1,4'-piperidine]; Siramesine free base; Lu-28-179; Lu 28-179; Lu28-179; Lu-28179; Lu 28179; Lu28179|
|Solubility||Soluble to ≥ 42 mg/mL in DMSO|
|Storage||Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -86℃ for long term (months to years).|
|Shelf Life||2 years|
SM-21 maleate is a potent and selective σ2 antagonist that can increase acetylcholine release at central muscarinic synapses. SM-21 is used as a potent analgesi...
BD1063 dhydrochloride is a potent and selective antagonist of sigma 1 receptor(Ki= 9.15 nM)with 50-fold more selective over sigma-2(Ki= 449 nM) and >100-fold mo...
PB 28 dihydrochloride
PB 28 dihydrochloride is a high affinity σ2 receptor agonist. It displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells.
N-[2-(Piperidinylamino)ethyl]-4-iodobenzamide is a selective ligand belongs to benzamides, therapeutic agents for human prostate tumors sigma-1, which binds wit...
The sigma-1 (σ1) receptor is an intracellular, non-opioid receptor that is abundantly expressed in the central nervous system as well as peripherally. S1RA is a...
NE 100 hydrochloride
NE 100 hydrochloride is a σ1 receptor antagonist with IC50 value of 4.16 nM. It displays antipsychotic activity in vivo.
PD 144418 oxalate
PD 144418 oxalate is a very selective sigma 1 agent (Ki values are 0.08 and 1377 nM for σ1 and σ2 respectively), devoid of any significant affinity for other re...
BD 1047 dihydrobromide
The dihydrobromide salt form of BD-1047, a selective σ1 receptor antagonist, has been found to have antipsychotic effect and could be probably used against schi...
BMY 14802 hydrochloride
BMY 14802 hydrochloride is a potent sigma receptor antagonist (IC50 = 112 nM) with weak affinity for 5-HT1A and α1 receptors. BMY 14802 is potentially used as a...
The hydrochloride salt form of S1RA which is a σ1 receptor antagonist that has been found to have potential effect in pain therapy. It is still under Phase II c...
4-PPBP, a piperidine derivative, is a σ ligand and selective non-competitive antagonist at recombinant NR1a/2B NMDA receptors expressed in Xenopus oocytes. It i...
Siramesine is a selective sigma-2 receptor agonist with a potent anticancer activity in vivo. It was originally devevloped for treating depressant and it has pr...
Noscapine is a phthalideisoquinoline alkaloid derived from the opium poppy Papaver somniferum, with mild analgesic, antitussive, and potential antineoplastic ac...
DTG has been found to be a σ-receptor agonist and is useful in studies of its interaction with dopamine drug.
SA-4503 is a potent sigma receptor agonist. SA-4503 may have effects on depressive symptoms such as agitation, loss of interest, and impaired cognition, which a...
TC 1 is a high affinity σ1 receptor ligand with selectivity over σ2 receptors (Ki = 10 and 370 nM respectively). TC 1 exhibits low affinity for dopamine (DAT), ...
L-693,403 maleate is the maleate salt of L-693,403, which is a sigma receptor-binding compound. It has excellent selectivity over the dopamine D2 receptor and b...
BD 1008 dihydrobromide
BD 1008 dihydrobromide is a potent and selective σ receptor antagonist displaying 4-fold selectivity for σ1 over σ2. BD-1008 attenuates the toxicity and stimula...
PRE-084 Hydrochloride is a selective sigma-1 agonist (Ki values are 2.2 and 13091 nM for σ1 and σ2 receptors respectively). PRE-084 is selective for PCP recepto...
Sigma-LIGAND-1, also called as NPC 16377, is a selective sigma receptor ligand developed for the treatment of neurological disorders and psychotic disorders in ...