|Description||Siguazodan is a selective phosphodiesterase 3 (PDE3) inhibitor (IC50 = 117 nM). Siguazodan acts as a potent vasodilator.|
|Brife Description||PDE3 inhibitor|
|Purity||≥99% by HPLC|
|Synonyms||N-Cyano-N'-methyl-N''-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]guanidine; SKF 94836; SKF-94836; SKF94836|
RVT-501, also referred to E6005, is a selective phosphodiesterase 4 (PDE4) inhibitor (IC50= 2.8 nM) with potential effect to treat atopic dermatitis.
PF 04449613 is a potent PDE9 inhibitor (IC50 = 22 nM), and also shows a high affinity for cGMP (Km ~170 nM). Some studies suggest that elevating the level of cG...
MY-5445 is a specific inhibitor of cyclic GMP phosphodiesterase, selective for PDE5, with a Ki value of 1.3 µM. It inhibits calcium- and cAMP-selective PDEs wit...
CI-1018 is a selective type 4 phosphodiesterase inhibitor associated with vasculitis. CI-1018 has been in development to suppress inflammation.
CK 3197 is a Phosphoric diester hydrolase inhibitor originated by Bayer HealthCare Pharmaceuticals. CK 3197 has hemodynamic and myocardial energetic effects. In...
HA-130, an effective autotaxin (ATX) inhibitor, has been found to restrain the cell migration related to ATX in in an A2058 melanoma cells. IC50: 28 nM.
Ibudilast is a nonselective inhibitor of cyclic nucleotide phosphodiesterase (PDE) which has been marketed for treating asthma. It crosses the blood-brain barri...
K134 is a selective phosphodiesterase 3 (PDE3) inhibitor, and has been shown to exhibit more potent anti-platelet activity than cilostazol. In vivo studies have...