Seladelpar - CAS 851528-79-5
Catalog number: B0084-476669
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C21H23F3O5S
Molecular Weight:
444.46
COA:
Inquire
Targets:
PPAR
Description:
Seladelpar is a selective peroxisome proliferator-activated receptor -δ receptor agonist. Phase II clinical trials for the treatment of Hyperlipidaemia, Hyperlipoproteinaemia type IIa and Primary biliary cirrhosis were on-going.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-476669 100 mg $598 In stock
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Purity:
98%
Appearance:
Powder
Synonyms:
MBX8025; RWJ-800025;(R)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetic acid
Solubility:
Soluble in DMSO
Storage:
-20℃ Freezer
MSDS:
Inquire
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
JWHYSEDOYMYMNM-QGZVFWFLSA-N
InChI:
1S/C21H23F3O5S/c1-3-27-17(11-28-16-6-4-15(5-7-16)21(22,23)24)13-30-18-8-9-19(14(2)10-18)29-12-20(25)26/h4-10,17H,3,11-13H2,1-2H3,(H,25,26)/t17-/m1/s1
Canonical SMILES:
CCO[C@H](COc1ccc(cc1)C(F)(F)F)CSc2ccc(OCC(=O)O)c(C)c2
Current Developer:
CymaBay Therapeutics
1.The selective peroxisome proliferator-activated receptor-delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in diabetic obese mice.
Haczeyni F;Wang H;Barn V;Mridha AR;Yeh MM;Haigh WG;Ioannou GN;Choi YJ;McWherter CA;Teoh NC;Farrell GC Hepatol Commun. 2017 Jul 31;1(7):663-674. doi: 10.1002/hep4.1072. eCollection 2017 Sep.
Lipotoxicity associated with insulin resistance is central to nonalcoholic steatohepatitis (NASH) pathogenesis. To date, only weight loss fully reverses NASH pathology, but mixed peroxisome proliferator-activated receptor-alpha/delta (PPAR-α/δ) agonists show some efficacy. Seladelpar (MBX-8025), a selective PPAR-δ agonist, improves atherogenic dyslipidemia. We therefore used this agent to test whether selective PPAR-δ activation can reverse hepatic lipotoxicity and NASH in an obese, dyslipidemic, and diabetic mouse model. From weaning, female ;Alms1; mutant (;foz/foz;) mice and wild-type littermates were fed an atherogenic diet for 16 weeks; groups (n = 8-12) were then randomized to receive MBX-8025 (10 mg/kg) or vehicle (1% methylcellulose) by gavage for 8 weeks. Despite minimally altering body weight, MBX-8025 normalized hyperglycemia, hyperinsulinemia, and glucose disposal in ;foz/foz; mice. Serum alanine aminotransferase ranged 300-600 U/L in vehicle-treated ;foz/foz; mice; MBX-8025 reduced alanine aminotransferase by 50%. In addition, MBX-8025 normalized serum lipids and hepatic levels of free cholesterol and other lipotoxic lipids that were increased in vehicle-treated ;foz/foz; versus wild-type mice.
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CAS 851528-79-5 Seladelpar

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