|Targets||5-HT Receptor | Adrenergic Receptor|
|Description||SDZ 21009 is a β-adrenoceptor and 5-HT1A/1B receptor antagonist (pKB/pA2 = 8.3 and 8.0 for 5-HT1A and 5-HT1B receptors, respectively).|
|Brife Description||β-adrenoceptor and 5-HT1A/1B receptor antagonist|
|Synonyms||Carpindolol; LM 21009; LM-21009; LM21009; SDZ 21009; SDZ21009; SDZ-21009; 4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-1H-indole-2-carboxylic acid, 1-methylethyl ester|
CGP 12177 hydrochloride
CGP 12177 hydrochloride is a partial agonist of β3-adrenoceptors, and also an antagonist of β1- and β2-adrenoceptors (Ki = 0.9, 4 and 88 nM for β1, β2 and β3 re...
Velusetrag is a selective, 5-HT4receptor agonist. Phase II clinical trials for the treatment of gastroparesis are on-going. Clnical trials for Alzheimer's disea...
Nebivolol, a highly selective β1-adrenergic receptor inhibitor, has vasodilatory effect so that could be effective against hypertension. It was just withdrawed ...
RS 100329 hydrochloride
RS 100329 is a selective α1A-adrenoceptor antagonist (pKi = 9.6 for human cloned α1A receptors), with 126- and 50-fold selectivity over human α1B and α1D recept...
A 5-HT1A receptor partial agonist that is less active compared to R-(+)-8-hydroxy-DPAT.
ICI141292, also known as Epanolol, is a adrenergic β-antagonist with a greater affinity for β1- than β2-adrenoceptors, which is used for treatment of hypertensi...
Terazosin is a selective alpha 1 antagonist used for treatment of symptoms of an enlarged prostate (BPH).
A major active metabolite of Buspirone and a 5-HT1A partial agonist. In comparison with the (R)-enantiomer, (S)-6-Hydroxybuspirone hydrochloride is cleared more...