|Description||Schisandrin C-induced apoptosis was associated with down-regulation of expression of the anti-apoptotic proteins Bcl-2 and Bcl-xL, proteolytic activation of caspase-3 and -9, and a concomitant degradation of poly(ADP-ribose) polymerase (PARP).Schisandrin C induced G1 arrest was correlated with down-regulation of cyclin D1, cyclin E, cyclin-dependent kinase (Cdk) 4 and E2Fs expression, inhibition of phosphorylation of retinoblastoma protein (pRB), and up-regulation of the Cdk inhibitor p21(WAF1/CIP1).|
|Synonyms||SCHIZANDRIN C; WUWEIZISU C; ,8-dimethyl-; cycloocta(1,2-f:3,4-f')bis(1,3)benzodioxole6,7,8,9-tetrahydro-1,13-dimethoxy-7; (6R,7S,13aS)-5,6,7,8-Tetrahydro-13,14-dimethoxy-6,7-dimethylcycloocta[1,2-f:3,4-f']bis[1,3]benzodioxole; (S)-(-)-Schisandrin C; Schisandrin C (S)-(-)-Schisandrin C|
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