Schisandrin A - CAS 61281-38-7
Catalog number: 61281-38-7
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
Schizandrin A is extracted from the seeds of Schisandra chinensis (Turcz.) Baill that is reported to have liver-protective, antitumor, and antioxidant activities in various research models.
Solid powder
Deoxyschizandrin; Dibenzo(a,c)cyclooctene, 5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-, (6R,7S,12aS)-;
Soluble in DMSO
Store at -20 °C
As an agonist of the adiponectin receptor 2 with an IC50 value of 3.5 µM.
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Canonical SMILES:
1.Schisandrin A and B induce organic anion transporting polypeptide 1B1 transporter activity.
Guo CX, Deng S, Yin JY, Liu ZQ, Zhang W, Zhou HH. Pharmazie. 2015 Jan;70(1):29-32.
Organic anion transporting polypeptide 1B1 (OATP1B1) is the most important transporter in the organic anion transporting polypeptide family. OATP1B1 plays an important role in the hepatic uptake of many endogenous compounds and xenobiotics, including many clinical drugs. At present, the combinational usage of Chinese traditional herbal medicines and conventional chemical pharmaceuticals may affect the activity of enzymes and transporters activity and cause absorption of their substrates and metabolic changes. In this study, we aimed to investigate the effect of schisandrin A, schisandrin B and tanshinone IIA, which were extracted from medicinal plants, on OATP1B1 activity. HepG2 cells are used as in vitro models for OATP1B1 activity studies. A combination of 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-tertazolium bromide (MTT) assays, real-time RT-PCR, and transporter activity analysis were employed. We found that schisandrin A and B increased OATP1B1 mRNA levels by 1.
2.Schizandrin A Inhibits Microglia-Mediated Neuroninflammation through Inhibiting TRAF6-NF-κB and Jak2-Stat3 Signaling Pathways.
Song F1, Zeng K2, Liao L2, Yu Q1, Tu P2, Wang X1. PLoS One. 2016 Feb 26;11(2):e0149991. doi: 10.1371/journal.pone.0149991. eCollection 2016.
Microglial-mediated neuroinflammation has been established as playing a vital role in pathogenesis of neurodegenerative disorders. Thus, rational regulation of microglia functions to inhibit inflammation injury may be a logical and promising approach to neurodegenerative disease therapy. The purposes of the present study were to explore the neuroprotective effects and potential molecular mechanism of Schizandrin A (Sch A), a lignin compound isolated from Schisandra chinesnesis. Our observations showed that Sch A could significantly down-regulate the increased production of nitric oxide (NO), tumor necrosis factor (TNF)-α and interleukin (IL)-6 induced by lipopolysaccharide (LPS) both in BV-2 cells and primary microglia cells. Moreover, Sch A exerted obvious neuroprotective effects against inflammatory injury in neurons when exposed to microglia-conditioned medium. Investigations of the mechanism showed the anti-inflammatory effect of Sch A involved the inhibition of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) expression levels and inhibition of the LPS-induced TRAF6-IKKβ-NF-κB pathway.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products

CAS 113240-27-0 Cgp 29030A

Cgp 29030A
(CAS: 113240-27-0)

This molecular is a piperazine derivative and its Pharmacological activity probablely is inhibition on nociceptive dorsal horn neurons that processed input from...

CAS 267402-71-1 Myoseverin

(CAS: 267402-71-1)

Myoseverin is a microtuble-binding molecule and reversible inhibitor of tubulin polymerization. It binds to tublin leading to myotube fission. Myoseverin affect...

CAS 478-01-3 Nobiletin

(CAS: 478-01-3)

Nobiletin, a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities.

CAS 68027-15-6 Pulsatilla saponin D

Pulsatilla saponin D
(CAS: 68027-15-6)

Pulsatilla saponin D, isolated from the root of Pulsatilla koreana, has exhibited potential beneficial effects as a chemopreventive agent for critical health co...

CAS 60-27-5 Creatinine

(CAS: 60-27-5)

Creatinine is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body.

CAS 107767-58-8 A-802715

(CAS: 107767-58-8)

A802715, a methylxanthine derivative, is an anti-tumor agent with a TD50 (toxic dose of 50%) of 0.9-1.1 mM.

CAS 864750-70-9 Revefenacin

(CAS: 864750-70-9)

Revefenacin, also knownc as TD-4208 and GSK1160724, is potent and selective muscarinic receptor antagonist in development for the treatment of COPD.

CAS 84366-81-4 FAD disodium salt

FAD disodium salt
(CAS: 84366-81-4)

FAD disodium salt is the salt form of FAD, which is a coenzyme that facilitates the transfer of electrons by flavoenzymes in oxidation-reduction reactions in ce...

Chemical Structure

CAS 61281-38-7 Schisandrin A

Quick Inquiry

Verification code

Featured Items