|Targets||Checkpoint Kinase (Chk)|
|Description||SCH900776 S-isomer is the S-isomer form of SCH900776, which is a potent, selective and orally bioavailable inhibitor of checkpoint kinase Chk1. It can be used as a protein kinase inhibitor useful in the treatment of protein kinase-mediated diseases. It enhances the γ-H2AX response of hydroxyurea, 5-fluoruracil, and cytarabine. It suppresses accumulation of the Chk1 pS296 autophosphorylation in a dose-dependent manner.|
|Synonyms||SCH900776 S-isomer; SCH 900776 S-isomer; SCH-900776 S-isomer; (S)-6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-A]pyrimidin-7-amine;6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-((3S)-piperidin-3-yl)pyrazolo(1,5-a)pyrimidin-7-amine;SCH-900776 S-isomer|
|Solubility||DMSO > 50 mg/mL Ethanol 3 mg/mL|
|Application||SCH900776 S-isomer can be used as a protein kinase inhibitor useful in the treatment of protein kinase-mediated diseases.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Quantity||Grams to Kilograms|
|Density||1.80±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
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