SCH900776 S-isomer - CAS 891494-64-7
Catalog number: 891494-64-7
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C15H18BrN7
Molecular Weight:
376.25
COA:
Inquire
Targets:
Checkpoint Kinase (Chk)
Description:
SCH900776 S-isomer is the S-isomer form of SCH900776, which is a potent, selective and orally bioavailable inhibitor of checkpoint kinase Chk1. It can be used as a protein kinase inhibitor useful in the treatment of protein kinase-mediated diseases. It enhances the γ-H2AX response of hydroxyurea, 5-fluoruracil, and cytarabine. It suppresses accumulation of the Chk1 pS296 autophosphorylation in a dose-dependent manner.
Purity:
>98%
Appearance:
Solid powder
Synonyms:
SCH900776 S-isomer; SCH 900776 S-isomer; SCH-900776 S-isomer; (S)-6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-A]pyrimidin-7-amine;6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-((3S)-piperidin-3-yl)pyrazolo(1,5-a)pyrimidin-7-amine;SCH-900776 S-isomer
Solubility:
DMSO > 50 mg/mL Ethanol 3 mg/mL
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
SCH900776 S-isomer can be used as a protein kinase inhibitor useful in the treatment of protein kinase-mediated diseases.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Grams to Kilograms
Density:
1.80±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
GMIZZEXBPRLVIV-VIFPVBQESA-N
InChI:
InChI=1S/C15H18BrN7/c1-22-8-10(6-19-22)11-7-20-23-14(17)12(16)13(21-15(11)23)9-3-2-4-18-5-9/h6-9,18H,2-5,17H2,1H3/t9-/m0/s1
Canonical SMILES:
CN1C=C(C=N1)C2=C3N=C(C(=C(N3N=C2)N)Br)C4CCCNC4
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