SC-9 - CAS 102649-78-5
Category: Inhibitor
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Molecular Formula:
Molecular Weight:
SC-9 is a potent activator of protein kinase C in the presence of Ca2+.
Brife Description:
PKC activator
≥99% by HPLC
Off-White to Pale Yellow Solid
SC-9; SC 9; SC9; 5-Chloro-N-(6-phenylhexyl)-1-naphthalenesulfonamide
Melting Point:
Canonical SMILES:
1.N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide, a novel activator of protein kinase C.
Ito M, Tanaka T, Inagaki M, Nakanishi K, Hidaka H. Biochemistry. 1986 Jul 29;25(15):4179-84.
Naphthalenesulfonamide derivatives were used to study the mechanism of regulation of Ca2+-dependent smooth muscle myosin light chain phosphorylation catalyzed by Ca2+-activated, phospholipid-dependent protein kinase (protein kinase C) and myosin light chain kinase. Derivatives such as N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide (SC-9), with a hydrophobic residue at the end of a hydrocarbon chain, stimulated Ca2+-activated, phospholipid-dependent myosin light chain phosphorylation in a Ca2+-dependent fashion. There was no significant effect of these compounds on Ca2+-calmodulin (CaM) dependent myosin light chain phosphorylation. On the other hand, derivatives with the guanidino or amino residue at the same position had an inhibitory effect on both Ca2+-phospholipid- and Ca2+-CaM-dependent myosin light chain phosphorylation. These observations suggest that activation of Ca2+-activated, phospholipid-dependent myosin light chain phosphorylation by naphthalenesulfonamide derivatives depends on the chemical structure at the end of hydrocarbon chain of each compound.
2.N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide is one of a new class of activators for Ca2+-activated, phospholipid-dependent protein kinase.
Nishino H, Kitagawa K, Iwashima A, Ito M, Tanaka T, Hidaka H. Biochim Biophys Acta. 1986 Nov 28;889(2):236-9.
N-(6-Phenylhexyl)-5-chloro-1-naphthalenesulfonamide (SC-9) activated Ca2+-activated, phospholipid-dependent protein kinase (protein kinase C). SC-9 acted as a substitute for phosphatidylserine, which is one of the endogenous factors in activating protein kinase C. SC-9 was also effective in regulating the physiological functions at the whole-cell level. For example, SC-9 stimulated hexose transport activity in mouse fibroblasts, a protein kinase C-regulated cellular function. Thus, SC-9 may be useful to study the molecular basis of the regulation of protein kinase C activity, and the biological significance of this enzyme.
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CAS 102649-78-5 SC-9

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