Sb-277011 - CAS 215803-78-4
Catalog number: 215803-78-4
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C28H30N4O
Molecular Weight:
438.56
COA:
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Targets:
Dopamine Receptor
Description:
Sb-277011 is a novel, high-anity and selective dopamine D3 receptor antagonist that may have potential in treating the negative symptoms of schizophrenia. pKi: 8.0, 6.0, 5.0 and <5.2 for D3, D2, 5-HT1D and 5-HT1B respectively
Appearance:
White Solid
Synonyms:
N-[4-[2-(6-cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]cyclohexyl]quinoline-4-carboxamide SB 277011 SB 277011-A SB-277011 SB-277011-A trans-N-(4-(2-(6-cyano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl)cyclohexyl)-4-quinolinecarboxamide
Solubility:
Soluble in DMSO
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -71℃ for long term (months to years).
MSDS:
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Shelf Life:
2 years
Boiling Point:
679.3±55.0 °C | Condition: Press: 760 Torr
Density:
1.23±0.1 g/cm3
InChIKey:
OLWRVVHPJFLNPW-UHFFFAOYSA-N
InChI:
1S/C28H30N4O/c29-18-21-5-8-23-19-32(16-13-22(23)17-21)15-12-20-6-9-24(10-7-20)31-28(33)26-11-14-30-27-4-2-1-3-25(26)27/h1-5,8,11,14,17,20,24H,6-7,9-10,12-13,15-16,19H2,(H,31,33)
Canonical SMILES:
C1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45
1.The selective dopamine D₃ receptor antagonist SB-277011-A significantly decreases binge-like consumption of ethanol in C57BL/J6 mice.
Rice OV1, Schonhar CA, Gaál J, Gardner EL, Ashby CR Jr. Synapse. 2015 Jun;69(6):295-8. doi: 10.1002/syn.21816.
The authors show that the dopamine D3 antagonist SB-277011-A consistently and persistently decrease binge-like EtOH consumption at 30 mg/kg and it decreases binge-like consumption on days 3, 7, 9, and 11-13 at 15 mg/kg. These findings suggest that the brain's D3 receptor may also be involved in not only ethanol reward but binge drinking as well.
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Chemical Structure

CAS 215803-78-4 Sb-277011

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