|Description||Sanguinarine caused cell death in a dose dependent manner in all neuroblastoma cell lines except SK-N-BE(2) with rates of 18% in SH-SY5Y and 21% in Kelly human neuroblastoma cells. Treatment with sanguinarine, but not berberine, inhibited the proliferation of Rac1b cells, which was accompanied by significantly increased the level of PARP-89, and decreased both the level of cyclin-D1 and the percentage of BrdU positive cells. Sanguinarine treatment resulted in a reduction of cell migration, in a dose-dependent inhibition of cell viability and in the induction of cell death by apoptosis in both human (MDA-MB-231 cells) and mouse (A17 cells) in vitro models of BLBC. SG pretreatment significantly increased the survival rate of mice from 25% to 58%, 75% and 91% respectively. The production of PGE2 in BALF, the lung MPO activity and the (W/D) weight ratios were also markedly reduced. In addition, immunohistochemical analysis showed that the expression of COX-2 was significantly suppressed in vivo. oral administration of sanguinarine reduced the development and growth of A17 transplantable tumors in FVB syngeneic mice.|
Clonidine is an α2-Adrenergic agonist for neuropathic pain.
TC-S 7006 is a potent, selective and reversible Tpl2 (Cot; MAP3K8) inhibitor (IC50 = 50 nM) with selectivity for Tpl2 over MEK, p38, Src, MK2, PKC and EGFR. TC-...
Ajugol is an iridiod glucoside isolated from the roots of Rehmannia glutinosa.
N-Desmethyl Ivabradine HCl
The hydrochloride salt form of N-Desmethyl Ivabradine which is an derivative of Ivabradine generated through metabolism.
Gemilukast 8 hydrate and disodium salt).
GSK376501A is a bio-active chemical compound used for the treatment of type 2 diabetes and hypercholesterolemia. It was developed by GlaxoSmithKline and was onc...
11β-HSD1-IN-1 is an inhibitor of 11β-hydroxydehydrogenase 1 (11β-HSD1) (IC50= 52 nM).
(+/-)-alpha-Lipoamide is a coenzyme, which transfer acetyl and hydrogen in Pyruvate deacylation oxidation process. It may be used in treatment of insulin resist...