Salidroside - CAS 10338-51-9
Catalog number: 10338-51-9
Category: Inhibitor
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Salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea, has been reported to have a broad spectrum of pharmacological properties.
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1. Combinative method using multi-components quantitation by single reference standard and HPLC fingerprint for comprehensive evaluation of Rhodiola crenulata H.Ohba
Yiyang Du, Qing Li, Jingjing Liu, Yidi Yinbc and Kaishun Bi*. Anal. Methods,2014, 6,5891–5898
In this study, SSDMC method, which has already applied in some TCM for resolving the problem of the expense and the limited availability of reference substances, was first used to determine phenolic compounds in R. crenulata. The three phenolic compounds salidroside, tyrosol and gallic acid, which have specific pharmacological activity and abundance in R. crenulata, were simultaneously determined with salidroside as the reference standard. The SSDMC method was validated, and its results were compared with those obtained by traditional ESM. Moreover, the same chromatographic condition was applied to fingerprint analysis for the further assessment of R. crenulata. The similarity evaluation system, HCA and PCA were performed to classify the samples from different origins, according to the characteristic of common peaks in ngerprint chromatograms. The aim of this study was to develop a direct, rapid and reliable HPLC-DAD method for quantitative analysis and establish the chromatographic fingerprint analysis for distinguishing R. crenulata from various locations. This combinative method can evaluate the quality of R. crenulata more comprehensively.
2. Development of adsorptive (non-ionic) macroporous resins and their uses in the purification of pharmacologically-active natural products from plant sources
Jing Li* and Howard A. Chase. Nat. Prod. Rep., 2010, 27, 1493–1510
Golden root (Rhodiola rosea) is a plant that is grown in the cold regions of the world and has been found to be effective for improving mood and alleviating depression. Salidroside (15, 4-hydroxyphenethyl)-β-D-glucopyranoside) is a phenylethanoid glycoside compound found in the extracts of golden root, and has been identified as a promising candidate responsible for the anti-depressant, anti-diabetic and antioxidative effects. Ma et al. made efforts to find a simple and efficient method to separate and purify salidroside from extracts of golden root at preparative scale. They investigated the static adsorption and desorption properties and kinetics of salidroside on five different macroporous adsorbents (D101, HPD-200, AB-8, HPD-600 and ADS-17). The performance of HPD-200 surpassed the other tested resins and was therefore used for further optimization of packed-bed separation processes.
3. Infrared-assisted extraction of salidroside from the root of Rhodiola crenulata with a novel ionic liquid that dissolves cellulose
Fajie Li, Yuan Yuan, Bin Yang* and Luqi Huang*. RSC Adv.,2015, 5, 47326–47333
The root of Rhodiola crenulata (Hook. f. et Thoms.) H. Ohba, which belongs to the family Crassulaceae and the genus Rhodiola, is particularly described in the Pharmacopoeia of China and it has been used for treating acute mountain sickness in Tibet since ancient times. Although salidroside is found in all species of the genus Rhodiola, R. crenulata contains the highest levels. Salidroside has recently attracted significant attention due to its pharmacological properties including anti-asthma, anticancer, hepatoprotective, neuroprotective, anti-oxidative effects and so on. Due to these beneficial effects, more attention has been focused on extraction and purification technologies for salidroside.
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CAS 10338-51-9 Salidroside

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