Salicin - CAS 138-52-3
Catalog number: B0084-058185
Category: Inhibitor
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Molecular Formula:
C13H18O7
Molecular Weight:
286.28
COA:
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Targets:
COX
Description:
Salicin is a phenol β-glycosid produced from willow bark that shows an anti-inflammatory effect. It acts as a non-selective COX inhibitor (IC50 values > 100 µM for COX-1 and COX-2).
Nutritional supplement in health care products.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-058185 250 g $489 In stock
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Brife Description:
COX inhibitor
Purity:
≥ 98%
Appearance:
White Solid
Synonyms:
Salicoside; NSC 5751; NSC-5751; NSC5751; Salicine; Salicyl alcohol glucoside; D-(-)-Salicin; (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[2-(hydroxymethyl)phenoxy]oxane-3,4,5-triol
MSDS:
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Application:
Ingredient of health care products.
Melting Point:
>201ºC (dec.)
InChIKey:
NGFMICBWJRZIBI-UJPOAAIJSA-N
InChI:
InChI=1S/C13H18O7/c14-5-7-3-1-2-4-8(7)19-13-12(18)11(17)10(16)9(6-15)20-13/h1-4,9-18H,5-6H2/t9-,10-,11+,12-,13-/m1/s1
Canonical SMILES:
C1=CC=C(C(=C1)CO)OC2C(C(C(C(O2)CO)O)O)O
1. Comparison of Molecular Mobility in the Glassy State Between Amorphous Indomethacin and Salicin Based on Spin-Lattice Relaxation Times
Katsuhiko Masuda, Sachio Tabata. Pharmaceutical Research, Vol. 22, No. 5, May 2005
Figure 5 shows typical solid-state 13C NMR spectra of amorphous salicin recorded with T1c measurement pulse sequences. The spectral patterns showed broad signals typical of amorphous material. In a similar manner as the indomethacin samples, amorphous salicin samples were stored at 293K, and X-ray diffraction analysis was confirmed that no crystallization had occurred. Spectral assignments for the solid-state spectra, based on the original solution-phase NMR assignments of HSQC and HMBC, are presented in Table II. Figure 6 shows the spinlattice relaxation process observed at 293 K, which is 40 K lower than Tg. The fitting of Mt/M0 for each signal of amorphous salicin was performed using the monodispersive relaxation mode of Eq. (1). As shown in Fig. 6, only signal 7 was fitted to Eq. (1) (i.e., the value of R2 was 0.990). This result indicates that signal 7 was consistent with the monodispersive relaxation mode. On the other hand, since signals 1, 2, 3, 4, 5, and 6 were not expressed by the monodispersive mode, these signals were analyzed in the multidispersive relaxation mode using Eq. (3). As shown in Fig. 7, signals 2, 3, 4, 5, and 6 were in good agreement with the simulated curves using Eq. (3), with two relaxation modes, and the R2 values were 0.997, 0.991, 0.991, 0.995, and 0.995, respectively. This also indicates that the relaxation of salicin did not occur in a homogeneous manner.
2. Effect of salicin on induction and carbon catabolite repression of endoxylanase synthesis in Penicillium janthinellum MTCC 10889
Aditi Kundu, Rina Rani Ray*. Chemical Papers 68 (4) 451–456 (2014)
The effect of various carbon sources on the endoxylanase production was studied by cultivating the strain in the presence of 0.5 % of various mono-, oligoand polysaccharides as the sole carbon source as well as in the absence of any particular carbon source. The effect of an additional carbon source to 0.5 % of xylan was examined using the previously used carbon sources at the concentration of 0.5 %. The effect of salicin on the enzyme production by the 0.5 % xylan induced culture was studied first by determining the optimum concentration of salicin, 0.1–0.5 %, followed by the evaluation of the optimum time of salicin incorporation with the xylan induced medium (0 h, 6 h, 24 h, 30 h, 48 h). Kinetics of the enzyme production and pH change in the presence of various carbon sources was monitored by cultivating the strain in the presence of various inducers and repressors in xylan induced cultivation media, collecting the aliquots of 24–144 h and measuring the enzyme production and pH change. In order to study the repressive effect of xylose in the xylan and salicin induced culture, enzyme activities were measured from the cultures where 0.5 % of xylose was added at various time intervals (0h,6h, 24h, 30h, 48h).Thestrategyadoptedfor the efficiency evaluation of salicin in the transcription and translation processes was the addition of various additives (0.1 %) to the xylan induced culture in the absence and presence of salicin. Each experiment was performed in triplicate and the obtained values were averaged.
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CAS 138-52-3 Salicin

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