Saikosaponin G - CAS 99365-19-2
Catalog number: B0005-479874
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Molecular Weight:
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Saikosaponin G, a triterpene glycoside, is a saikosaponin which is believed to be responsible for part of the pharmaceutical properties of Bupleuri Radix. Bupleuri Radix, dried roots of Bupleurum spp. (Apiaceae), has been used as medicine in China for over 2000 years, and it is one of the most common components of Chinese traditional medicine prescriptions for the treatment of chronic hepatitis, kidney syndrome, inflammatory diseases, and ulcers of the digestive system.
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Catalog Number Size Price Stock Quantity
B0005-479874 10mg $889 In stock
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> 98%
White solid powder
(3β,4α,16β)-16,23,28-Trihydroxyoleana-9(11),12-dien-3-yl 6-deoxy-3-O-β-D-glucopyranosyl-β-D-galactopyranoside
Soluble in DMSO
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -42℃ for long term (months to years).
Quality Standard:
Enterprise Standard
Boiling Point:
903.5±65.0 °C | Condition: Press: 760 Torr
1.35±0.1 g/cm3
1.Structural transformation of saikosaponins by gastric juice and intestinal flora.
Shimizu K;Amagaya S;Ogihara Y J Pharmacobiodyn. 1985 Sep;8(9):718-25.
Structural transformation of saikosaponin a and saikosaponin d, main components of Bupleuri Radix, were investigated using rat gastric juice (pH 1.5) and mouse intestinal flora in vitro and the excretion of saikosaponin derivatives in rat feces was also studied. Quantitative analysis of saikosaponins and their derivatives was carried out by high performance liquid chromatography. By the incubation of saikosaponins in rat gastric juice, saikosaponin a decreased with time dependently. After 3 h, saikosaponin a disappeared completely and saikosaponin b1 which possessed heteroannular diene moiety at C-11,13(18) and saikosaponin g which possessed homoannular diene moiety at C-9(11),12 were detected with the ratio of 3:1. On the other hand, saikosaponin d rapidly changed to only saikosaponin b2 (heteroannular diene structure) completely 30 min after the incubation. Next, by the anaerobic incubation of saikosaponin a with mouse intestinal flora, the formation of saikogenin F, a genuine aglycone of saikosaponin a, reached to the maximum 1 h after the incubation and its yield was 80%. A minor peak of prosaikogenen F, a monofucoside of saikogenin F, was also detected at 15 min. By the same procedures, saikosaponin b1, g, d and b2 also changed to the corresponded prosaikogenin A, H, G and D and saikogenin A, H, G and D with the almost similar pattern to that of saikosaponin a.
2.Corticosterone secretion-inducing activity of saikosaponin metabolites formed in the alimentary tract.
Nose M;Amagaya S;Ogihara Y Chem Pharm Bull (Tokyo). 1989 Oct;37(10):2736-40.
The corticosterone secretion-inducing activities of saikosaponin a, saikosaponin c and saikosaponin d, isolated from the root of Bupleurum falcatum L., and 27 metabolites formed in the murine alimentary tract were studied in mice. Serum corticosterone was determined by high-performance liquid chromatography (HPLC). Intraperitoneal administration of saikosaponin a and its intestinal metabolite, prosaikogenin F, showed corticosterone secretion-inducing activity at a dose of 0.1 mmol/kg, and maximally increased it at a dose of 0.4 mmol/kg. On the other hand, the genuine sapogenin, saikogenin F, was inactive. Saikosaponin b1 and saikosaponin g, gastric metabolites of saikosaponin a, and their intestinal metabolites, prosaikogenin A, prosaikogenin H, saikogenin A and saikogenin H, were also inactive. Serum corticosterone was increased by the administration of saikosaponin d and its intestinal metabolite, prosaikogenin G, at a dose of 0.04 mmol/kg, and it reached the maximal level at the dose of 0.1 mmol/kg. Saikogenin G also showed a slight activity. A gastric metabolite of saikosaponin d, saikosaponin b2, and its intestinal metabolites, prosaikogenin D and saikogenin D, were inactive. In the experiments on saikosaponin c and its metabolites, saikosaponin c was inactive but its intestinal metabolites, especially prosaikogenin E-2, showed activity almost equal to that of saikosaponin a.
3.ELISA for the determination of saikosaponin a, an active component of Bupleuri Radix.
Jung DW;Shibuya M;Ebizuka Y;Yoshimatsu K;Shimomura K;Sung CK Chem Pharm Bull (Tokyo). 1998 Jul;46(7):1140-3.
In order to quantify saikosaponin a (SSA), one of the major active components of Bupleuri Radix, a competitive and indirect ELISA method was developed. High titer rabbit polyclonal antibodies (pAbs) were raised against a conjugate of SSA and bovine serum albumin, coupled with a periodate oxidation method. SSA competitively inhibited the binding of rabbit anti-SSA pAbs to SSA-ovalbumin on the solid phase, a coated antigen on the well. The quantity of pAbs bound to the well was monitored using a peroxidase-conjugated anti-rabbit IgG as a secondary antibody, and tetramethylbenzidine solution as a substrate. The measuring range extended from 50 pg/ml to 20 ng/ml of SSA, with a detection limit of 40 pg/ml (5.13 pM). Antibodies showed some cross-reactivity with saikosaponin c (12.74%). However, the antibodies showed only slight cross-reactivities with saikosaponin d (0.3%), which differs from SSA only in the stereochemistry of the 16-hydroxyl group, and the artificial saikosaponins, saikosaponin b1 (2.1%) and saikosaponin g (0.53%). The specific and sensitive ELISA is especially suited for determination of SSA in samples when only small quantities of materials can be extracted for analysis.
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CAS 99365-19-2 Saikosaponin G

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