|Description||SAG is a potent and cell-permeable Smoothened (Smo) receptor agonist that regulates hedgehog signaling. SAG inhibits hedgehog signaling at high concentrations.|
|Brife Description||Smo receptor agonist|
|Purity||≥99% by HPLC|
|Related CAS||912545-86-9 (free base)|
BMS-833923, also known as XL-139, is an orally bioavailable small-molecule SMO (Smoothened) inhibitor with potential antineoplastic activity. SMO antagonist BMS...
GSA-10 is a quinolinecarboxamide derivative that acts as aSmoothened (Smo) receptor agonist (EC50 = 1.2 μM). Smoothened (SMO) is a cell surface receptor that, w...
MRT-92 HCl salt
MRT-92 is a selective Smoothened (Smo) receptor inhibitor. It shows subnanomolar antagonist activity against Smo in various Hh cell-based assays. MRT-92 inhibit...
SMANT hydrochloride is an inhibitor of Smoothened (Smo) signaling via a unique mechanism. SMANT inhibits both wild-type Smo and an oncogenic form (SmoM2) with s...
MK-4101 is a potent and selective SMO Inhibitor of the Hedgehog Pathway with anti-tumor activity. MK-4101 targets the Hh pathway in tumor cells, showing the max...
SANT-2 is an inhibitor of Sonic hedgehog (Shh) signaling and an antagonist of smoothened receptor activity (KD = 12 nM). SANT-2 exhibits smo-[3H]SAG-1.3 and -[3...
This active molecular is a novel potent Smoothened antagonist. MRT-83 blocks Hedgehog (Hh) signaling in various assays and IC50 can be in nmol range, showing gr...
SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); sag antagonizes cyclopamine action at the Smo receptor.