|Description||The sigma-1 (σ1) receptor is an intracellular, non-opioid receptor that is abundantly expressed in the central nervous system as well as peripherally. S1RA is a potent, selective antagonist of σ1 receptors (Ki = 17 nM) that weakly binds σ2 receptors (Ki = 9,300 nM).|
TC 1 is a high affinity σ1 receptor ligand with selectivity over σ2 receptors (Ki = 10 and 370 nM respectively). TC 1 exhibits low affinity for dopamine (DAT), ...
The sigma-1 (σ1) receptor is an intracellular, non-opioid receptor that is abundantly expressed in the central nervous system as well as peripherally. S1RA is a...
Rimcazole dihydrochloride is a small molecule antagonist of the σ-1 receptor (IC50 values are 1480 and 386 nM at σ1 and σ2 receptors respectively).
The hydrochloride salt form of S1RA which is a σ1 receptor antagonist that has been found to have potential effect in pain therapy. It is still under Phase II c...
SA-4503 is a potent sigma receptor agonist. SA-4503 may have effects on depressive symptoms such as agitation, loss of interest, and impaired cognition, which a...
BD 1008 dihydrobromide
BD 1008 dihydrobromide is a potent and selective σ receptor antagonist displaying 4-fold selectivity for σ1 over σ2. BD-1008 attenuates the toxicity and stimula...
BD1063 dhydrochloride is a potent and selective antagonist of sigma 1 receptor(Ki= 9.15 nM)with 50-fold more selective over sigma-2(Ki= 449 nM) and >100-fold mo...
DTG has been found to be a σ-receptor agonist and is useful in studies of its interaction with dopamine drug.