S-(+)-O-Desmethyl-Venlafaxine - CAS 142761-12-4
Catalog number: 142761-12-4
Molecular Formula:
C16H25NO2
Molecular Weight:
263.38
COA:
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Description:
S-(+)-O-Desmethyl-Venlafaxine is a metabolite of Venlafaxine. Venlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) that is used as an antidepressant. According to different doses, it effects on serotonergic transmission, noradrenergic systems and dopaminergic neurotransmission. Venlafaxine is commonly used to treat depression, general anxiety disorder, social phobia, panic disorder, and vasomotor symptoms.
Appearance:
White to Off-White Solid
Synonyms:
(S)-(+)-4-[2-(Dimethylamino)-1-(1-hydroxycyclo-hexyl)ethyl]phenol
MSDS:
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Melting Point:
235-237°C
1.Crystal forms of the hydrogen oxalate salt of o-desmethylvenlafaxine.
Dichiarante E1, Curzi M1, Giaffreda SL1, Grepioni F2, Maini L2, Braga D2. J Pharm Pharmacol. 2015 Jun;67(6):823-9. doi: 10.1111/jphp.12378. Epub 2015 Feb 3.
OBJECTIVES: To prepare new crystalline forms of the antidepressant o-desmethylvenlafaxine salt as potential new commercial forms and evaluate their physicochemical properties, in particular the dissolution rate.
2.Management of Newer Antidepressant Medications in U.S. Commercial Health Plans.
Hodgkin D1, Horgan CM, Creedon TB, Merrick EL, Stewart MT. J Ment Health Policy Econ. 2015 Dec;18(4):165-73.
BACKGROUND: Private health insurance plays a large role in the U.S. health system, including for many individuals with depression. Private insurers have been actively trying to influence pharmaceutical utilization and costs, particularly for newer and costlier medications. The approaches that insurers use may have important effects on patients' access to antidepressant medications.
3.Effects of desvenlafaxine on blood pressure in patients treated for major depressive disorder: a pooled analysis.
Thase ME1, Fayyad R, Cheng RF, Guico-Pabia CJ, Sporn J, Boucher M, Tourian KA. Curr Med Res Opin. 2015 Apr;31(4):809-20. doi: 10.1185/03007995.2015.1020365. Epub 2015 Mar 26.
OBJECTIVE: To evaluate the effect of the serotonin-norepinephrine re-uptake inhibitor desvenlafaxine on blood pressure and incidence of new onset hypertension in pooled short-term studies and in two longer-term, randomized withdrawal studies.
4.Development of an enantioselective assay for simultaneous separation of venlafaxine and O-desmethylvenlafaxine by micellar electrokinetic chromatography-tandem mass spectrometry: Application to the analysis of drug-drug interaction.
Liu Y1, Jann M2, Vandenberg C3, Eap CB4, Shamsi SA5. J Chromatogr A. 2015 Nov 13;1420:119-28. doi: 10.1016/j.chroma.2015.09.088. Epub 2015 Oct 3.
To-date, there has been no effective chiral capillary electrophoresis-mass spectrometry (CE-MS) method reported for the simultaneous enantioseparation of the antidepressant drug, venlafaxine (VX) and its structurally-similar major metabolite, O-desmethylvenlafaxine (O-DVX). This is mainly due to the difficulty of identifying MS compatible chiral selector, which could provide both high enantioselectivity and sensitive MS detection. In this work, poly-sodium N-undecenoyl-L,L-leucylalaninate (poly-L,L-SULA) was employed as a chiral selector after screening several dipeptide polymeric chiral surfactants. Baseline separation of both O-DVX and VX enantiomers was achieved in 15 min after optimizing the buffer pH, poly-L,L-SULA concentration, nebulizer pressure and separation voltage. Calibration curves in spiked plasma (recoveries higher than 80%) were linear over the concentration range 150-5000 ng/mL for both VX and O-DVX. The limit of detection (LOD) was found to be as low as 30 ng/mL and 21 ng/mL for O-DVX and VX, respectively.
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CAS 142761-12-4 S-(+)-O-Desmethyl-Venlafaxine

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