S-Adenosyl-L-Methionine-d3
Molecular Formula:
C15H19N6O5SD3
Molecular Weight:
401.46
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Tag:
Free Amino Acids & Derivatives (Labelled)
Description:
S-Adenosyl-L-Methionine-d3 is a labelled S-Adenosyl-L-Methionine. S-Adenosyl-L-Methionine plays important roles in the liver such as a precursor cysteine, a methylating agent, an anti-inflammatory agent.
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Purity:
95% by HPLC; 98% atom D
Related CAS:
29908-03-0 (unlabelled)
Appearance:
Solid Powder
Synonyms:
(2S)-2-Amino-4-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-methylsulfonio]butanoate-d3; S-adenosylmethionine-d3
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1.Pharmacodynamic studies on the central mode of action of S-adenosyl-L-methionine (SAMe) infusions in elderly subjects, utilizing EEG mapping and psychometry
B. Saletu, P. Anderer, L. Linzmayer. J Neural Transm (2002) 109: 1505–1526
S-adenosyl-L-methionine (SAMe), or ademetionine, a naturally occurring molecule, is found in all living organisms. In humans, it is distributed throughout virtually all body tissues and fluids, with highest concentrations in childhood, decreasing with age. Synthesized from methionine and adenosine triphosphate (ATP) in a reaction catalyzed by methionine adenosyltransferase (MAT), SAMe acts as a major methyl donor in enzymatic transmethylation reactions (Stramentinoli, 1987). Moreover, through transsulfuration it is a precursor of essential amino acids including cysteine, taurine and glutathione (Friedel et al., 1989). Via transmethylation, methyl groups (-CH3) are transferred by SAMe to various molecules, such as nucleic acids, proteins, phospholipids, hormones, neurotransmitters, catecholamines and other biogenic amines. Phospholipids, which are integral constituents of biological membranes, play a crucial role in many membrane functions such as iron transport, receptoreffector coupling, secretion of biogenic amines etc. (Baldessarini, 1987; Stramentinoli, 1987). That is why transmethylation, an essential step in the biosynthesis of phospholipids, has a major impact on physicochemical properties of membranes like fluidity and consequently affects important functions such as receptor-effector coupling (Hirata and Axelrod, 1980). With age, the methylation process of phospholipids is attenuated, which reduces the fluidity of the membranes and thus the efficiency of the beta-adrenergic receptors. SAMe intake in elderly people has been proved to prevent this decrease of the methylation process in membranes.
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