S-acetylglutathione - CAS 3054-47-5
Catalog number: 3054-47-5
Category: Intermediates
Molecular Formula:
C12H19N3O7S
Molecular Weight:
349.36016;g/mol
COA:
Inquire
Purity:
98%
Synonyms:
(2S)-5-[[(2R)-3-acetylsulfanyl-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-2-amino-5-oxopentanoicacid; S-Acetylglutathione; 3054-47-5; AmbotzLS-1270; Glutathione,S-acetate; SCHEMBL2017370
MSDS:
Inquire
Quantity:
Data not available, please inquire.
Boiling Point:
770.2ºC at 760mmHg
Density:
1.436g/cm3
InChIKey:
FVRWSIPJNWXCEO-YUMQZZPRSA-N
InChI:
InChI=1S/C12H19N3O7S/c1-6(16)23-5-8(11(20)14-4-10(18)19)15-9(17)3-2-7(13)12(21)22/h7-8H,2-5,13H2,1H3,(H,14,20)(H,15,17)(H,18,19)(H,21,22)/t7-,8-/m0/s1
Canonical SMILES:
CC(=O)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)N
1.Reduced glutathione and S-acetylglutathione as selective apoptosis-inducing agents in cancer therapy.
Donnerstag B1, Ohlenschlager G, Cinatl J, Amrani M, Hofmann D, Flindt S, Treusch G, Träger L. Cancer Lett. 1996 Dec 20;110(1-2):63-70.
The effect of reduced glutathione (GSH) and S-acetylglutathione (S-acglu) treatment on several tumor cell lines and normal cells in vitro was investigated. GSH and S-acglu applied at concentrations of 1 mM and 2 mM induced apoptosis in malignant cells as shown by DNA-fragmentation and staining of apoptotic cells with 7-amino-actinomycin D while viability and growth of normal cells were not significantly influenced by this treatment. The results demonstrated that GSH and S-acglu may be selective inducers of apoptosis in malignant cells.
2.Effects of S-acetylglutathione in cell and animal model of herpes simplex virus type 1 infection.
Vogel JU1, Cinatl J, Dauletbaev N, Buxbaum S, Treusch G, Cinatl J Jr, Gerein V, Doerr HW. Med Microbiol Immunol. 2005 Jan;194(1-2):55-9. Epub 2003 Nov 18.
Intracellular glutathione (GSH) plays an important regulatory role in the host response to viral infections. Replenishment of intracellular GSH is a desirable yet challenging goal, since systemic GSH supplementation is rather inefficient due to a short half-life of GSH in blood plasma. Further, GSH is not taken up by cells directly, but needs to be broken down into amino acids and resynthesized to GSH intracellularly, this process often being impaired during viral infections. These obstacles may be overcome by a novel glutathione derivative S-acetylglutathione (S-GSH), which is more stable in plasma and taken up directly by cells with subsequent conversion to GSH. In the present study, in vitro effects of supplementation with S-GSH or GSH on intracellular GSH levels, cell survival and replication of human herpes simplex virus type 1 (HSV-1) were studied in human foreskin fibroblasts. In addition, in vivo effects of supplementation with S-GSH or GSH on HSV-1-induced mortality were studied in hr/hr mice.
3.S-Acetylglutathione normalizes intracellular glutathione content in cultured fibroblasts from patients with glutathione synthetase deficiency.
Okun JG1, Sauer S, Bähr S, Lenhartz H, Mayatepek E. J Inherit Metab Dis. 2004;27(6):783-6.
Glutathione synthetase deficiency is an autosomal recessive inherited metabolic defect in the gamma-glutamyl cycle. Decreased intracellular glutathione levels are one of the characteristic biochemical features. In this study we show that addition of S-acetylglutathione to the medium raised intracellular glutathione content in cultured fibroblasts from patients with glutathione synthetase deficiency. This has implications for the treatment of patients with this inborn error of metabolism.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 564-87-4 11-Cis retinal

11-Cis retinal
(CAS: 564-87-4)

CAS 61788-44-1 styrenated phenol

styrenated phenol
(CAS: 61788-44-1)

CAS 1555-56-2 Sodium Glycerophosphate

Sodium Glycerophosphate
(CAS: 1555-56-2)

CAS 24599-25-5 ACRYLAMIDO BUFFER

ACRYLAMIDO BUFFER
(CAS: 24599-25-5)

CAS 280755-12-6 Tulathromycin

Tulathromycin
(CAS: 280755-12-6)

CAS 1072-53-3 Ethylenesulfate

Ethylenesulfate
(CAS: 1072-53-3)

CAS 130525-62-1 Zanamivir Amine

Zanamivir Amine
(CAS: 130525-62-1)

Zanamivir Amine is used as a precursor in the synthesis of Zanamivir.

CAS 285138-82-1 ACRYLIC ACID-D4

ACRYLIC ACID-D4
(CAS: 285138-82-1)

Chemical Structure

CAS 3054-47-5 S-acetylglutathione

Quick Inquiry

Verification code

Featured Items