|Description||(S)-4-Carboxyphenylglycine has been found to be a competitive group I metabotropic glutamate receptor antagonist(S)-4-Carboxyphenylglycine has been found to be a competitive group I metabotropic glutamate receptor antagonist and selective for mGluR1.|
|Purity||≥99% by HPLC|
|Synonyms||(S)-4CPG; (S)-4C-PG; (S)-4-Carboxyphenylglycine; (S)-4C-PG; (αS)-α-Amino-4-carboxybenzeneacetic Acid|
Ro 01-6128 is a positive allosteric modulator of mGluR1 that potentiates glutamate-induced calcium release (EC50 = 104 nM). Ro 01-6128 activates ERK1/2 phosphor...
AIDA is a selective group I mGluR agonist and could show centrally active following systemic administration in vivo.
(2R,4R)-APDC is a selective and relatively potent group II mGluR agonist (EC50 = 0.4, 0.4, > 100, > 100, > 300 and > 300 μM for human mGlu2, mGlu3, mGlu1, mGlu5...
VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displa...
ADX 10059 hydrochloride
The hydrochloride salt form of ADX 10059, which has been reported to be a negative allosteric modulator.
MSPG is a non-selective antagonist of presynaptic mGluRs.
VU 0360172 hydrochloride
VU 0360172 hydrochloride is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM) with potential antipsychotic-like activity. VU 036017...
LSN 2463359 is an allosteric modulator at the mGlu5 receptor with EC50 value of 24 nM. It is brain penetrant and can reverse learning deficits in a rat model of...