|Description||(S)-3-Carboxy-4-hydroxyphenylglycine has been found to be a mixed group II mGlu agonist as well as group I metabotropic glutamate receptor antagonist.|
|Purity||≥98% by HPLC|
VU 0469650 hydrochloride
VU 0469650 hydrochloride is a potent and selective negative allosteric modulator of mGlu1 (IC50 = 99 nM), displaying >100-fold selectivity for mGlu1 over mGlu2-...
O-Phospho-L-serine, a molecule which resembles phosphatidylserine head group, is an agonist of the group III metabotropic glutamate receptors mGluR4a and mGluR6...
ATPA is a potent and selective GluR5 kainate receptor agonist with Ki value of 4.3 nM. It is weakly active at AMPA receptors (GluR1-4), GluR7 and the kainate re...
Dipraglurant is a mGlu5 receptor negative allosteric modulator. It is currently in phase II for the treatment of dyskinesia in Parkinson's disease.
JNJ-42153605 is a selective positive allosteric modulator of the metabotropic glutamate 2 (mGlu2) receptor (EC50= 17 Nm) with an acceptable pharmacokinetic prof...
SIB 1757 is a highly selective antagonist for the metabotropic glutamate mGlu5 receptor subtype (IC50 = 0.4 μM and > 30 μM at hmGlu5, hmGlu1b, hmGlu2, hmGlu4, h...
Sodium salt of LY 379268. LY 379268 is a group II mGlu receptor agonist with EC50 values of 2.69 and 4.48 nM for hmGlu2 and hmGlu3. Some research shows that LY3...
(S)-HexylHIBO is a Group I mGlu receptor antagonist (Kb = 30 and 61 μM at mGlu1a and mGlu5a receptors, respectively).