|Description||Rucaparib, also known as (AG-14699 or PF-01367338, is a tricyclic indole poly(ADP-Ribose) polymerase (PARP1) inhibitor with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Rucaparib selectively binds to PARP1 and inhibits PARP1-mediated DNA repair, thereby enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. This may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapy and radiation therapy. PARP1 catalyzes post-translational ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks.|
|Appearance||Light yellow solid powder|
|Synonyms||AG-14699 (as phosphate salt), AG-014447 (as free base); PF-01367338; AG 14699 (as phosphate salt), AG 014447 (as free base); PF 01367338; AG14699 (as phosphate salt), AG014447 (as free base); PF01367338|
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