|Description||(RS)-PPG is a potent and selective group III metabotropic glutamate receptor (mGluR) agonist, with approximately 25-fold selectivity for hmGlu8. (RS)-PPG exhibits anticonvulsant and neuroprotective properties in vivo.|
|Brife Description||group III mGluR agonist|
|Synonyms||(RS)-4-Phosphonophenylglycine; 2-amino-2-(4-phosphonophenyl)acetic acid|
VU 29 is a potent positive allosteric potentiator at the rat mGlu5 receptor (EC50 = 9 nM) with selectivity for mGlu5 over mGlu1 and mGlu2 receptors (EC50 = 557 ...
LY-404,039, also known as pomaglumetad, is an amino acid analog drug that acts as a highly selective agonist for the metabotropic glutamate receptor group II su...
(±)-LY 395756 is a mixed mGlu2 agonist/mGlu3 antagonist.
CHPG is a selective metabotropic glutamate 5 (mGlu5) receptor agonist, and it is inactive in CHO cells. CHPG potentiates NMDA-induced depolarizations in rat hip...
Desmethyl-YM 298198 is a derivative of YM 298198, a selective antagonist of mGlu1.
Dipraglurant is a mGlu5 receptor negative allosteric modulator. It is currently in phase II for the treatment of dyskinesia in Parkinson's disease.
VU 0422288 is a group III mGlu receptor positive allosteric modulator (EC50 = 108, 125 and 146 nM for mGlu4, mGlu8 and mGlu7, respectively) with selectivity ove...
DCB is an allosteric ligand for the metabotropic glutamate receptor mGlu5 that displays neutral modulation. It inhibits the modulation of mGlu5 by other alloste...