RS 25344 hydrochloride - CAS 152815-28-6
Category: Inhibitor
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Molecular Formula:
C19H13N5O4.HCl
Molecular Weight:
411.8
COA:
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Targets:
Phosphodiesterase (PDE)
Description:
RS 25344 hydrochloride is a potent and selective inhibitor of four cloned isoforms of PDE4 (A, B, C and D) and phosphorylated PDE4D (IC50= 0.28, > 100, 160 and 330 nM at PDE4, PDE1, PDE2 and PDE3 respectively). It has been shown to inhibit eosinophil chemotaxis and increase progressive motility of spermatozoa in vitro.
Purity:
≥98% by HPLC
Related CAS:
152814-89-6 (free base)
Synonyms:
1-(3-Nitrophenyl)-3-(4-pyridinylmethyl)-pyrido[2,3-d]pyrimidine-2,3-(1H,3H)-dione hydrochloride; RS-25344 HCl; RS 25344 HCl; RS25344 HCl
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
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InChIKey:
NYZOOMDEQVWPGI-UHFFFAOYSA-N
InChI:
InChI=1S/C19H17N5O4.ClH/c25-19-22(16-4-1-5-17(11-16)23(26)27)18-15(3-2-8-21-18)13-24(19,28)12-14-6-9-20-10-7-14;/h1-7,9-11,21H,8,12-13H2;1H
Canonical SMILES:
C1=CC(=CC(=C1)[N+](=O)[O-])N2C3=C(C=CC=N3)C(=O)N(C2=O)CC4=CC=NC=C4.Cl
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CAS 152815-28-6 RS 25344 hydrochloride

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