|Description||RN 1747, a selective TRPV4 agonist (EC50= 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively), represents the first drug-like TRPV4 antagonist with selectivity over closely related TRP channels. The activities of these compounds were characterized using two different systems: Ca2+ influx assay with human, mouse and rat TRPV4-expressing HEK293 cells and electrophysiology in hTRPV4-transfected Xenopus oocytes. Importantly, RN-1734 antagonized both ligand-gated activation and hypotonicity-induced opening of TRPV4 in both types of assay.|
|Synonyms||1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine; RN1747; RN 1747; RN-1747|
|Storage||Store in a cool and dry place (or refer to the Certificate of Analysis).|
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