RN 1747 - CAS 1024448-59-6
Category: Inhibitor
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Molecular Formula:
C17H18ClN3O4S
Molecular Weight:
395.87
COA:
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Targets:
TRP Channel
Description:
RN 1747, a selective TRPV4 agonist (EC50= 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively), represents the first drug-like TRPV4 antagonist with selectivity over closely related TRP channels. The activities of these compounds were characterized using two different systems: Ca2+ influx assay with human, mouse and rat TRPV4-expressing HEK293 cells and electrophysiology in hTRPV4-transfected Xenopus oocytes. Importantly, RN-1734 antagonized both ligand-gated activation and hypotonicity-induced opening of TRPV4 in both types of assay.
Synonyms:
1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine; RN1747; RN 1747; RN-1747
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
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InChIKey:
ZNLVYSJQUMALEO-UHFFFAOYSA-N
InChI:
InChI=1S/C17H18ClN3O4S/c18-15-6-7-17(16(12-15)21(22)23)26(24,25)20-10-8-19(9-11-20)13-14-4-2-1-3-5-14/h1-7,12H,8-11,13H2
Canonical SMILES:
C1CN(CCN1CC2=CC=CC=C2)S(=O)(=O)C3=C(C=C(C=C3)Cl)[N+](=O)[O-]
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CAS 1024448-59-6 RN 1747

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