Risedronate Sodium - CAS 115436-72-1
Catalog number: 115436-72-1
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
Risedronate Sodium is a bisphosphonate used to strengthen bone, treat or prevent osteoporosis, and treat Paget's disease of bone.
NE 58095 Sodium; NE58095 Sodium; NE-58095 Sodium
Canonical SMILES:
1.Use of risedronate for consolidation and callus formation in Colles fractures in postmenopausal women: SOLID study.
Oliveira LG1, Eis SR2, Neto HM3, de Moraes FB4, Pires LA5, Vasconcelos JW6. Rev Bras Ortop. 2015 Apr 17;50(3):274-82. doi: 10.1016/j.rboe.2015.04.004.
in English, PortugueseOBJETIVO: Este estudo multicêntrico, randomizado, aberto, grupo paralelo avaliou a eficácia de Actonel® 35 mg mais cálcio/vitamina D versus cálcio/vitamina D isoladamente na preservação da densidade mineral óssea (DMO) em mulheres pós-menopausadas com fratura de Colles.
2.Enteric-coated tablet of risedronate sodium in combination with phytic acid, a natural chelating agent, for improved oral bioavailability.
Kim JS1, Jang SW1, Son M1, Kim BM1, Kang MJ2. Eur J Pharm Sci. 2016 Jan 20;82:45-51. doi: 10.1016/j.ejps.2015.11.011. Epub 2015 Dec 1.
The oral bioavailability (BA) of risedronate sodium (RS), an antiresorptive agent, is less than 1% due to its low membrane permeability as well as the formation of non-absorbable complexes with multivalent cations such as calcium ion (Ca(2+)) in the gastrointestinal tract. In the present study, to increase oral BA of the bisphosphonate, a novel enteric-coated tablet (ECT) dosage form of RS in combination with phytic acid (IP6), a natural chelating agent recognized as safe, was formulated. The chelating behavior of IP6 against Ca(2+), including a stability constant for complex formulation was characterized using the continuous variation method. Subsequently, in vitro dissolution profile and in vivo pharmacokinetic profile of the novel ECT were evaluated comparatively with that of the marketed product (Altevia, Sanofi, US), an ECT containing ethylenediaminetetraacetic acid (EDTA) as a chelating agent, in beagle dogs. The logarithm of stability constant for Ca(2+)-IP6 complex, an equilibrium constant approximating the strength of the interaction between two chemicals to form complex, was 19.
3.Evaluation of risedronate as an antibiofilm agent.
Reshamwala SM1, Mamidipally C2, Pissurlenkar RR3, Coutinho EC4, Noronha SB5. J Med Microbiol. 2016 Jan;65(1):9-18. doi: 10.1099/jmm.0.000193. Epub 2015 Oct 23.
Escherichia coli cra null mutants have been reported in the literature to be impaired in biofilm formation. To develop E. coli biofilm-inhibiting agents for prevention and control of adherent behaviour, analogues of a natural Cra ligand, fructose-1,6-bisphosphate, were identified based on two-dimensional similarity to the natural ligand. Of the analogues identified, those belonging to the bisphosphonate class of drug molecules were selected for study, as these are approved for clinical use in humans and their safety has been established. Computational and in vitro studies with purified Cra protein showed that risedronate sodium interacted with residues in the fructose-1,6-bisphosphate-binding site. Using a quantitative biofilm assay, risedronate sodium, at a concentration of 300-400 μM, was found to decrease E. coli and Salmonella pullorum biofilm formation by >60 %. Risedronate drastically reduced the adherence of E. coli cells to a rubber Foley urinary catheter, demonstrating its utility in preventing the formation of biofilm communities on medical implant surfaces.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products

(CAS: 126595-07-1)

Propagermanium is an organometallic compound of germanium that is sold as an alternative medicine for the treatment of Hepatitis B under the development of Aste...

CAS 920509-32-6 MGL-3196

(CAS: 920509-32-6)

MGL-3196 is a first-in-class, orally available, once-daily and liver-directed thyroid hormone receptor (THR) beta-selective agonist. Studies suggest that MGL-31...

ABT 38396
(CAS: 4853-98-9)

ABT 38396 is a synthetic bio-active chemical.

CAS 129623-01-4 GR 82334

GR 82334
(CAS: 129623-01-4)

GR 82334 is a tachykinin NK1 receptor antagonist.

CAS 383150-41-2 JTE-013

(CAS: 383150-41-2)

JTE-013 is a potent and selective sphingosine-1-phosphate (S1P) receptor 2 (S1P2) antagonist (IC50=17.6 nM).

CAS 739-71-9 trimipramine

(CAS: 739-71-9)

Trimipramine is a tricyclic antidepressant. It is serotonin and norepinephrine transport inhibitor with antipsychotic and sedative properties.

BMS 433771
(CAS: 380603-10-1)

BMS 433771 is a potent inhibitor of RSV replication in vitro with an average EC of 20nM

CAS 12279-41-3 ACTH (1-39)

ACTH (1-39)
(CAS: 12279-41-3)

ACTH (1-39) is the major regulator of adrenal cortex function and could stimulate the synthesis of steroidal hormones.

Chemical Structure

CAS 115436-72-1 Risedronate Sodium

Quick Inquiry

Verification code

Featured Items