Risedronate Sodium - CAS 115436-72-1
Catalog number: 115436-72-1
Category: Inhibitor
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Molecular Formula:
C7H10NNaO7P2
Molecular Weight:
305.09
COA:
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Targets:
Others
Description:
Risedronate Sodium is a bisphosphonate used to strengthen bone, treat or prevent osteoporosis, and treat Paget's disease of bone.
Purity:
>98%
Synonyms:
NE 58095 Sodium; NE58095 Sodium; NE-58095 Sodium
MSDS:
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InChIKey:
DRFDPXKCEWYIAW-UHFFFAOYSA-M
InChI:
InChI=1S/C7H11NO7P2.Na/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6;/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15);/q;+1/p-1
Canonical SMILES:
C1=CC(=CN=C1)CC(O)(P(=O)(O)O)P(=O)(O)[O-].[Na+]
1.Use of risedronate for consolidation and callus formation in Colles fractures in postmenopausal women: SOLID study.
Oliveira LG1, Eis SR2, Neto HM3, de Moraes FB4, Pires LA5, Vasconcelos JW6. Rev Bras Ortop. 2015 Apr 17;50(3):274-82. doi: 10.1016/j.rboe.2015.04.004.
in English, PortugueseOBJETIVO: Este estudo multicêntrico, randomizado, aberto, grupo paralelo avaliou a eficácia de Actonel® 35 mg mais cálcio/vitamina D versus cálcio/vitamina D isoladamente na preservação da densidade mineral óssea (DMO) em mulheres pós-menopausadas com fratura de Colles.
2.Enteric-coated tablet of risedronate sodium in combination with phytic acid, a natural chelating agent, for improved oral bioavailability.
Kim JS1, Jang SW1, Son M1, Kim BM1, Kang MJ2. Eur J Pharm Sci. 2016 Jan 20;82:45-51. doi: 10.1016/j.ejps.2015.11.011. Epub 2015 Dec 1.
The oral bioavailability (BA) of risedronate sodium (RS), an antiresorptive agent, is less than 1% due to its low membrane permeability as well as the formation of non-absorbable complexes with multivalent cations such as calcium ion (Ca(2+)) in the gastrointestinal tract. In the present study, to increase oral BA of the bisphosphonate, a novel enteric-coated tablet (ECT) dosage form of RS in combination with phytic acid (IP6), a natural chelating agent recognized as safe, was formulated. The chelating behavior of IP6 against Ca(2+), including a stability constant for complex formulation was characterized using the continuous variation method. Subsequently, in vitro dissolution profile and in vivo pharmacokinetic profile of the novel ECT were evaluated comparatively with that of the marketed product (Altevia, Sanofi, US), an ECT containing ethylenediaminetetraacetic acid (EDTA) as a chelating agent, in beagle dogs. The logarithm of stability constant for Ca(2+)-IP6 complex, an equilibrium constant approximating the strength of the interaction between two chemicals to form complex, was 19.
3.Evaluation of risedronate as an antibiofilm agent.
Reshamwala SM1, Mamidipally C2, Pissurlenkar RR3, Coutinho EC4, Noronha SB5. J Med Microbiol. 2016 Jan;65(1):9-18. doi: 10.1099/jmm.0.000193. Epub 2015 Oct 23.
Escherichia coli cra null mutants have been reported in the literature to be impaired in biofilm formation. To develop E. coli biofilm-inhibiting agents for prevention and control of adherent behaviour, analogues of a natural Cra ligand, fructose-1,6-bisphosphate, were identified based on two-dimensional similarity to the natural ligand. Of the analogues identified, those belonging to the bisphosphonate class of drug molecules were selected for study, as these are approved for clinical use in humans and their safety has been established. Computational and in vitro studies with purified Cra protein showed that risedronate sodium interacted with residues in the fructose-1,6-bisphosphate-binding site. Using a quantitative biofilm assay, risedronate sodium, at a concentration of 300-400 μM, was found to decrease E. coli and Salmonella pullorum biofilm formation by >60 %. Risedronate drastically reduced the adherence of E. coli cells to a rubber Foley urinary catheter, demonstrating its utility in preventing the formation of biofilm communities on medical implant surfaces.
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CAS 115436-72-1 Risedronate Sodium

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