Rimantadine - CAS 13392-28-4
Catalog number: 13392-28-4
Category: Inhibitor
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Molecular Formula:
C12H21N
Molecular Weight:
179.30
COA:
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Targets:
Influenza Virus
Description:
Rimantadine, an adamantane derivative, could be an effective antiviral drug and probably prevent influenza virus at some extent.
Purity:
95%
Appearance:
Powder
Synonyms:
1-(1-Adamantyl)ethanamine;1-Adamantanemethylamine, alpha-methyl-;alpha-Methyl-1-adamantanemethylamine;alpha-Methyladamantanemethylamine;Tricyclo(3.3.1.13,7)decane-1-methanamine, alpha-methyl-;Tricyclo[3,3,1,1(3,7)]decane-1-methanamine, alpha-m
Solubility:
DMSO 33 mg/mL; Water 33 mg/mL
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
Rimantadine could be an effective antiviral drug and probably prevent influenza virus at some extent.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Boiling Point:
248ºC
Density:
1.033 g/cm3
InChIKey:
UBCHPRBFMUDMNC-UHFFFAOYSA-N
InChI:
InChI=1S/C12H21N/c1-8(13)12-5-9-2-10(6-12)4-11(3-9)7-12/h8-11H,2-7,13H2,1H3
Canonical SMILES:
CC(C12CC3CC(C1)CC(C3)C2)N
1.[3-substituted analogs of remantadine: synthesis and antiherpetic activity in Vero cells].
Moiseev IK;Andronova VL;Pozdniakov VV;Makarova NV;Galegov GA Antibiot Khimioter. 2002;47(11):9-12.
Chemical synthesis of 3-substituted analogues of remantadine is described. Derivatives IIIb and IIIc when compared with remantadine had not only potent activity against ethalon herpes simplex type 1 virus strain but also were active against herpes virus resistant to aciclovir. Compound IIIc demonstrated virulecidal effect. Combination of IIIc + aciclovir had additive effect against ethalon herpes simplex type 1 virus strain. Investigated 3-substituted analogues demonstrated low activity in the model system of influenzae virus. No antiviral activity was demonstrated in the model system of Syndbys virus (though compounds were evaluated in subtoxic concentrations).
2.[Pathology of the reproductive apparatus of cells under the action of remantadine and deitiforin].
Votiakov VI;Erokhina IR;Amvros'eva TV;Rusiaev VA Biull Eksp Biol Med. 1989 Sep;108(9):356-8.
The antiviral effect of chemical agents remantadine and deutephorine on the reproductive apparatus of MDCK-cells was studied. It was established that the action of the chemical agents during 3-4 days induced enhancement in pathologically transformed mitoses. This enhancement was in direct proportion to the doses used and to the cultivation time. Dose dependent enhancement of the total pathological mitoses number was simultaneous with the redistribution of mitoses into groups: the relative number of pathologies connected with chromosome damage became lower and the number of degenerating mitoses grew. Computer regression analysis showed the linear dependence between the chemical agent dose and the number of mitoses in the metaphase, that gives an indirect evidence of statmokinetic action of the agents under study.
3.Simultaneous determination of antiviral drugs in chicken tissues by ultra high performance liquid chromatography with tandem mass spectrometry.
Liu Z;Yang F;Yao M;Lin Y;Su Z J Sep Sci. 2015 May;38(10):1784-93. doi: 10.1002/jssc.201401461. Epub 2015 May 6.
An ultra high performance liquid chromatography with tandem mass spectrometry method was established for the rapid and simultaneous analysis of seven antiviral drugs, amantadine, rimantadine, memantine, moroxydine, imiquimod, oseltamivir, and acyclovir, in chicken liver, muscle, and egg. Homogenized samples were extracted with trichloroacetic acid and acetonitrile solutions and then purified by cation-exchange solid-phase extraction. The target drugs were analyzed by liquid chromatography with a UPLC BEH Amide column (2.1 mm × 100 mm, 1.7 μm) coupled with a tandem mass spectrometer operating in the positive multiple-reaction mode. A perfectly linear relationship was obtained within the concentration ranges of 0.5-20 μg/L for acyclovir and 0.1-10 μg/L for the other six antiviral drugs. The average recoveries of the seven antiviral drugs using four addition levels in chicken liver, muscle, and eggs were 82.67-90.10, 82.30-92.27, and 81.98-93.77%, respectively, and the acceptable coefficients of variation were 5.18-9.88, 4.84-11.2, and 42.8-9.95%, respectively. The detection limits and detection capabilities of the analysis method for the seven antiviral drugs were in the ranges of 0.04-0.
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