RGW2938 - CAS 111786-07-3
Category: Inhibitor
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Molecular Formula:
C13H14N4O2
Molecular Weight:
258.28
COA:
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Targets:
Phosphodiesterase (PDE)
Description:
A phosphodiesterase inhibitor
Synonyms:
RGW2938; RGW 2938; RGW-2938; 2(1H)​-​Quinazolinone, 3,​4-​dihydro-​3-​methyl-​6-​(1,​4,​5,​6-​tetrahydro-​6-​oxo-​3-​pyridazinyl)​-
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
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Melting Point:
> 250 ℃
Density:
1.47±0.1 g/cm3
InChIKey:
SUCNEHPNQBBVHQ-UHFFFAOYSA-N
InChI:
InChI=1S/C13H14N4O2/c1-17-7-9-6-8(2-3-10(9)14-13(17)19)11-4-5-12(18)16-15-11/h2-3,6H,4-5,7H2,1H3,(H,14,19)(H,16,18)
Canonical SMILES:
CN1CC2=C(C=CC(=C2)C3=NNC(=O)CC3)NC1=O
1.Pharmacology of RG W-2938: a cardiotonic agent with vasodilator activity.
Barrett JA;Woltmann RF;Swillo RS;Kasiewski C;Faith WC;Campbell HF;Perrone MH J Cardiovasc Pharmacol. 1990 Oct;16(4):537-45.
The cardiovascular effects of RG W-2938, 6-[6-(3,4-dihydro-3-methyl-2(1H)-2-oxoquinazolinyl)]-4,5-dihydro-3 (2H-pyridazinone, a new nonglycoside, noncatecholamine cardiotonic/vasodilator agent were examined in vivo in anesthetized and conscious dogs and in vitro in isolated guinea pig hearts; in the latter, RG W-2938 5 nmol-5 mumol increased contractility in a dose-related fashion. RG W-2938 30-300 micrograms/kg administered intravenously (i.v.) to anesthetized dogs increased contractile force while decreasing arterial pressure and total peripheral resistance (TPR) in a dose-related manner. Heart rate (HR) was only slightly increased, and aortic flow was not appreciably altered. A single oral dose of RG W-2938 0.3 mg/kg administered to conscious chronically instrumented dogs produced a marked and sustained increase in contractility 15-240 min after treatment while only slightly increasing HR. The effects of RG W-2938 30-300 micrograms/kg, i.v. were studied in a mecamylamine-propranolol-induced model of heart failure. RG W-2938 effectively reversed the drug-induced heart failure by increasing myocardial contractility and decreasing arterial pressure while only slightly affecting HR. These studies show that RG W-2938 is an orally effective positive inotropic/vasodilator agent.
2.Ethyl 6-(4-cyclo-propyl-1H-1,2,3-triazol-1-yl)pyridine-3-carboxyl-ate.
Ahmed MN;Yasin KA;Tahir MN;Bibi A;Andleeb H Acta Crystallogr Sect E Struct Rep Online. 2014 Jan 15;70(Pt 2):o136. doi: 10.1107/S1600536813034673. eCollection 2014 Feb 1.
In the title compound, C13H14N4O2, which has approximate mirror symmetry, the dihedral angles between the triazole ring and the cyclo-propane and pyridine rings are 87.1 (2) and 7.60 (9)°, respectively. In the crystal, inversion dimers linked by pairs of both C-H⋯N and C-H⋯O inter-actions generate R 2 (2)(6) and R 2 (2)(18) loops, respectively. Further C-H⋯N inter-actions form R 2 (2)(10) loops and link the dimers into [110] chains.
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CAS 111786-07-3 RGW2938

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