RG3039 - CAS 1005504-62-0
Catalog number: 1005504-62-0
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C21H23Cl2N5O
Molecular Weight:
432.35
COA:
Inquire
Targets:
Others
Description:
RG3039 is a potent DcpS inhibitor. It is used for the treatment for spinal muscular atrophy(SMA), which is caused by deletion or mutation of both copies of the SMN1 gene. It improves motor function in SMA mice. It also showed activity to improve survival, function and motor unit pathologies in two SMA mouse models. It was developed by Repligen and now in Clinic Phase 1 with no progress.
Purity:
>98 %
Appearance:
White to off- white solid powder
Synonyms:
RG3039; RG 3039; RG-3039; PF06687859; PF 06687859; PF-06687859. 5-((1-(2,6-dichlorobenzyl)piperidin-4-yl)methoxy)quinazoline-2,4-diamine;5-[[1-[(2,6-dichlorophenyl)methyl]piperidin-4-yl]methoxy]quinazoline-2,4-diamine
Solubility:
10 mM in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
RG3039 is used for the treatment for spinal muscular atrophy(SMA).
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Grams to Kilograms
Boiling Point:
648.1±65.0 °C | Condition: Press: 760 Torr
Density:
1.375±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
MNLHFGXIUJNDAF-UHFFFAOYSA-N
InChI:
InChI=1S/C21H23Cl2N5O/c22-15-3-1-4-16(23)14(15)11-28-9-7-13(8-10-28)12-29-18-6-2-5-17-19(18)20(24)27-21(25)26-17/h1-6,13H,7-12H2,(H4,24,25,26,27)
Canonical SMILES:
C1CN(CCC1COC2=CC=CC3=C2C(=NC(=N3)N)N)CC4=C(C=CC=C4Cl)Cl
Current Developer:
RG3039 was developed by Repligen and now in Clinic Phase 1 with no progress.
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