|Description||RG3039 is a potent DcpS inhibitor. It is used for the treatment for spinal muscular atrophy(SMA), which is caused by deletion or mutation of both copies of the SMN1 gene. It improves motor function in SMA mice. It also showed activity to improve survival, function and motor unit pathologies in two SMA mouse models. It was developed by Repligen and now in Clinic Phase 1 with no progress.|
|Appearance||White to off- white solid powder|
|Synonyms||RG3039; RG 3039; RG-3039; PF06687859; PF 06687859; PF-06687859. 5-((1-(2,6-dichlorobenzyl)piperidin-4-yl)methoxy)quinazoline-2,4-diamine;5-[[1-[(2,6-dichlorophenyl)methyl]piperidin-4-yl]methoxy]quinazoline-2,4-diamine|
|Solubility||10 mM in DMSO|
|Application||RG3039 is used for the treatment for spinal muscular atrophy(SMA).|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Quantity||Grams to Kilograms|
|Boiling Point||648.1±65.0 °C | Condition: Press: 760 Torr|
|Density||1.375±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
|Current Developer||RG3039 was developed by Repligen and now in Clinic Phase 1 with no progress.|
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