Resiniferonol 9,13,14-Orthophenylacetate - CAS 57852-42-3
Catalog number: 57852-42-3
Category: Inhibitor
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Molecular Formula:
Molecular Weight:
Resiniferonol 9,13,14-Orthophenylacetate, a 20-Deacylated derivative of resiniferatoxin and tinyatoxin, is a transient receptor potential vanilloid-1 (TRPV1) agonist.
Solid powder
6,7-Deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(phenylmethyl)daphnetoxin; [2S-(2α,3aβ,3bβ,6aβ,9aα,9bα,10α,11aβ)]-3a,3b,6,6a,9a,10,11,11a-Octahydro-6a-hydroxy-5-(hydroxymethyl)-8,10-dimethyl-11a-(1-methylethenyl)-2-(phenylmethyl)-7H-2,9b-Epoxyazuleno[5,4-e]-1,3-benzodioxol-7-one; Resiniferonol 9,13,14-ortho-phenylacetate; 57852-42-3; CTK8G2927
Soluble in DMSO, and 100% ethanol
Desiccate at -20°C
Boiling Point:
638.0±55.0 °C | Condition: Press: 760 Torr
1.32±0.1 g/cm3
Canonical SMILES:
1.Preparedness for threat of chikungunya in the pacific.
Roth A, Hoy D, Horwood PF, Ropa B, Hancock T, Guillaumot L, Rickart K, Frison P, Pavlin B, Souares Y. Emerg Infect Dis. 2014 Aug;20(8). doi: 10.3201/eid2008.130696.
Chikungunya virus (CHIKV) caused significant outbreaks of illness during 2005-2007 in the Indian Ocean region. Chikungunya outbreaks have also occurred in the Pacific region, including in Papua New Guinea in 2012; New Caledonia in April 2013; and Yap State, Federated States of Micronesia, in August 2013. CHIKV is a threat in the Pacific, and the risk for further spread is high, given several similarities between the Pacific and Indian Ocean chikungunya outbreaks. Island health care systems have difficulties coping with high caseloads, which highlights the need for early multidisciplinary preparedness. The Pacific Public Health Surveillance Network has developed several strategies focusing on surveillance, case management, vector control, laboratory confirmation, and communication. The management of this CHIKV threat will likely have broad implications for global public health.
2.Attitudes towards euthanasia among Greek intensive care unit physicians and nurses.
Kranidiotis G1, Ropa J2, Mprianas J3, Kyprianou T4, Nanas S2. Heart Lung. 2015 May-Jun;44(3):260-3. doi: 10.1016/j.hrtlng.2015.03.001. Epub 2015 Apr 1.
OBJECTIVES: To investigate the attitudes of Greek intensive care unit (ICU) medical and nursing staff towards euthanasia.
3.Unrepeatered 256 Gb/s PM-16QAM transmission over up to 304 km with simple system configurations.
Downie JD, Hurley J, Roudas I, Pikula D, Garza-Alanis JA. Opt Express. 2014 May 5;22(9):10256-61. doi: 10.1364/OE.22.010256.
We study unrepeatered transmission of 40x256 Gb/s systems with polarization-multiplexed 16-quadrature amplitude modulation (PM-16QAM) channels using simple coherent optical system configurations. Three systems are investigated with either a homogeneous fiber span, or simple two-segment hybrid fiber designs. Each system relies primarily on ultra-low loss, very large effective area fiber, while making use of only first-order backward pumped Raman amplification and no remote optically pumped amplifier (ROPA). For the longest span studied, we demonstrate unrepeatered 256 Gb/s transmission over 304 km with the additional aid of nonlinear compensation using digital backpropagation. We find an average performance improvement in terms of the Q-factor of 0.45 dB by using digital backpropagation compared to the case of using chromatic dispersion compensation alone for an unrepeatered span system.
4.Evaluation of the effects of Streptococcus mutans chaperones and protein secretion machinery components on cell surface protein biogenesis, competence, and mutacin production.
Crowley PJ1, Brady LJ1. Mol Oral Microbiol. 2016 Feb;31(1):59-77. doi: 10.1111/omi.12130. Epub 2015 Oct 7.
The respective contributions of components of the protein translocation/maturation machinery to cell surface biogenesis in Streptococcus mutans are not fully understood. Here we used a genetic approach to characterize the effects of deletion of genes encoding the ribosome-associated chaperone RopA (Trigger Factor), the surface-localized foldase PrsA, and the membrane-localized chaperone insertases YidC1 and YidC2, both singly and in combination, on bacterial growth, chain length, self-aggregation, cell surface hydrophobicity, autolysis, and antigenicity of surface proteins P1 (AgI/II, PAc), WapA, GbpC, and GtfD. The single and double deletion mutants, as well as additional mutant strains lacking components of the signal recognition particle pathway, were also evaluated for their effects on mutacin production and genetic competence.
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CAS 57852-42-3 Resiniferonol 9,13,14-Orthophenylacetate

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