Ravuconazole - CAS 182760-06-1
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C22H17F2N5OS
Molecular Weight:
437.47
COA:
Inquire
Targets:
Antifungal
Description:
Ravuconazole, also known as BMS-207147 or ER-30346, is a potent, broad spectrum and broad spectrum triazoleantifungle agent and an ergosterol biosynthesis inhibitor.
Brife Description:
An orally available triazoleantifungle agent
Synonyms:
Ravuconazole; BMS-207147; ER-30346 ; BMS207147; ER30346 ; ER30346. 4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl]benzonitrile; BMS 207147; ER 30346
Solubility:
10 mM in DMSO
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Boiling Point:
674.9±65.0 ℃ at 760 Torr
Density:
1.38±0.1 g/cm3
InChIKey:
OPAHEYNNJWPQPX-RCDICMHDSA-N
InChI:
1S/C22H17F2N5OS/c1-14(21-28-20(10-31-21)16-4-2-15(9-25)3-5-16)22(30,11-29-13-26-12-27-29)18-7-6-17(23)8-19(18)24/h2-8,10,12-14,30H,11H2,1H3/t14-,22+/m0/s1
Canonical SMILES:
CC(C1=NC(=CS1)C2=CC=C(C=C2)C#N)C(CN3C=NC=N3)(C4=C(C=C(C=C4)F)F)O
1.Madurella mycetomatis is highly susceptible to ravuconazole.
Ahmed SA1, Kloezen W2, Duncanson F3, Zijlstra EE4, de Hoog GS5, Fahal AH6, van de Sande WW2. PLoS Negl Trop Dis. 2014 Jun 19;8(6):e2942. doi: 10.1371/journal.pntd.0002942. eCollection 2014.
The current treatment of eumycetoma utilizing ketoconazole is unsatisfactory because of high recurrence rates, which often leads to complications and unnecessary amputations, and its comparatively high cost in endemic areas. Hence, an effective and affordable drug is required to improve therapeutic outcome. E1224 is a potent orally available, broad-spectrum triazole currently being developed for the treatment of Chagas disease. E1224 is a prodrug that is rapidly converted to ravuconazole. Plasma levels of E1224 are low and transient, and its therapeutically active moiety, ravuconazole is therapeutically active. In the present study, the in vitro activity of ravuconazole against Madurella mycetomatis, the most common etiologic agent of eumycetoma, was evaluated and compared to that of ketoconazole and itraconazole. Ravuconazole showed excellent activity with MICs ranging between ≤ 0.002 and 0.031 µg/ml, which were significantly lower than the MICs reported for ketoconazole and itraconazole.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Antifungal Products


CAS 142128-59-4 (+)-Ketoconazole

(+)-Ketoconazole
(CAS: 142128-59-4)

(+)-Ketoconazole, an imidazole anti-fungal agent, has often produced features of androgen deficiency including decreased libido, gynecomastia, impotence, oligos...

CAS 118021-35-5 L-4-Oxalysine hydrochloride

L-4-Oxalysine hydrochloride
(CAS: 118021-35-5)

L-4-oxalysine is a natural product isolated from a new species of Streptomyces roseoÍiridofuscus n.sp. in China. L-4-oxalysine inhibits the proliferation of som...

CAS 135575-42-7 Pneumocandin B0

Pneumocandin B0
(CAS: 135575-42-7)

Pneumocandin B0, also called as L 688786, is an inhibitor of ß-(1,3)-D-glucan (a component of fungal cell walls) synthesis with an antifungal effect (IC50s = 70...

CAS 171228-49-2 Posaconazole

Posaconazole
(CAS: 171228-49-2)

Posaconazole is a sterol C14ɑ demethylase inhibitor with an IC50 of 0.25 nM.

CAS 2022-85-7 Flucytosine

Flucytosine
(CAS: 2022-85-7)

The combination of Flucytosine and IgGl monoclonal antibody to Cryptococcus neoformans capsular glucuronoxylomannan is more effective in reducing the numbers of...

CAS 174672-06-1 AN2718

AN2718
(CAS: 174672-06-1)

AN2718, a novel boron-containing small molecule, is a member of a new class of antifungals, benzoxaboroles, which inhibit fungal growth by blocking protein synt...

CAS 101827-46-7 Butenafine HCl

Butenafine HCl
(CAS: 101827-46-7)

Butenafine HCl is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.

CAS 22832-87-7 Miconazole Nitrate

Miconazole Nitrate
(CAS: 22832-87-7)

Miconazole is an imidazole antifungal agent, developed by Janssen Pharmaceutica, commonly applied topically to the skin or to mucous membranes to cure fungal in...

Chemical Structure

CAS 182760-06-1 Ravuconazole

Quick Inquiry

Verification code

Featured Items