|source\Analogue Sets||Streptomyces | Tacrolimus Analogue Set|
|Description||A triene macrolide; a metabolite of streptomyces hygroscopicus; displayed potent and selective antifungal activity, notably against candida albicans; inhibits the activity of the protein, mtor (mammalian target of rapamycin) which functions in a signalling pathway to promote tumour growth; binds to a receptor protein (FKBP12)|
|Purity||>99% by HPLC|
|Synonyms||Sirolimus, AY 22989, SIIA 9268A|
|Solubility||Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.|
The major analogue of a family of adenosine nucleosides containing a complex tricyclic saccharide; a potent herbicide with selective activity against dicotyledo...
A histone deacetylase inhibitor that enhances the cytotoxic efficacy of anticancer drugs that target DNA; shows antifungal, antiprotozoan and antitumour activit...
An antibiotic; a more hydrophobic analogue of thiolutin
A macrocyclic heptaene antifungal complex produced by streptomyces griseus; the candicidin complex comprises analogues A, B, C and D, with candicidin D as the m...
An unusual aminoglycoside containing a nitrosoamino group produced by streptomyces achromogenes; an antibiotic; a nitric oxide (NO) donor; widely used to induce...
A macrocyclic lactone closely related to tacrolimus and rapamycin; isolated from several species of streptomyces; exhibits limited, potent antifungal activity; ...
Everolimus is an inhibitor of mammalian target of rapamycin (mTOR) with an immunosuppressive activity which is comparable to that of rapamycin. It inhibits cyto...
An isochromanequinone; structurally related to lactoquinomycin; inhibits thrombin-induced aggregation of human platelets; active against gram positive and gram ...