rac-Rotigotine Hydrochloride - CAS 102120-99-0
Catalog number: 102120-99-0
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C19H26ClNOS
Molecular Weight:
351.93
COA:
Inquire
Targets:
Dopamine Receptor
Description:
The hydrochloride salt form of rac-Rotigotine, a mixture of S- and R-Rotigotine, is an effective and highly selective D-2 receptor agonist which could be used in the treatment of the Parkinson's disease. Ki: 0.69 nM.
Purity:
95%
Appearance:
White Solid
Synonyms:
5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol Hydrochloride;
Solubility:
10 mM in DMSO
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
The hydrochloride salt form of rac-Rotigotine is an effective and highly selective D-2 receptor agonist which could be used in the treatment of the Parkinson's disease.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
CEXBONHIOKGWNU-UHFFFAOYSA-N
InChI:
InChI=1S/C19H25NOS.ClH/c1-2-11-20(12-10-17-6-4-13-22-17)16-8-9-18-15(14-16)5-3-7-19(18)21;/h3-7,13,16,21H,2,8-12,14H2,1H3;1H
Canonical SMILES:
CCCN(CCC1=CC=CS1)C2CCC3=C(C2)C=CC=C3O.Cl
1.LC-MS Method for Studying the Pharmacokinetics and Bioequivalence of Clonidine Hydrochloride in Healthy Male Volunteers.
Danafar H1, Hamidi M2. Avicenna J Med Biotechnol. 2016 Apr-Jun;8(2):91-98.
BACKGROUND: A simple and sensitive high performance liquid chromatography-electrospray ionization mass spectrometry method has been evaluated for the assignment of clonidine hydrochloride in human plasma.
2.Terbinafine Hydrochloride Trans-ungual Delivery via Nanovesicular Systems: In Vitro Characterization and Ex Vivo Evaluation.
Elsherif NI1, Shamma RN2, Abdelbary G1. AAPS PharmSciTech. 2016 May 2. [Epub ahead of print]
Treating a nail infection like onychomycosis is challenging as the human nail plate acts as a formidable barrier against all drug permeation. Available oral and topical treatments have several setbacks. Terbinafine hydrochloride (TBH), belonging to the allylamine class, is mainly used for treatment of onychomycosis. This study aims to formulate TBH in a nanobased spanlastic vesicular carrier that enables and enhances the drug delivery through the nail. The nanovesicles were formulated by ethanol injection method, using either Span® 60 or Span® 65, together with Tween 80 or sodium deoxycholate as an edge activator. A full factorial design was implemented to study the effect of different formulation and process variables on the prepared TBH-loaded spanlastic nanovesicles. TBH entrapment efficiency percentages, particle size diameter, percentage drug released after 2 h and 8 h were selected as dependent variables. Optimization was performed using Design-Expert® software to obtain an optimized formulation with high entrapment efficiency (62.
3.Doxorubicin hydrochloride-oleic acid conjugate loaded nanostructured lipid carriers for tumor specific drug release.
Zhao S1, Minh LV2, Li N3, Garamus VM4, Handge UA5, Liu J6, Zhang R3, Willumeit-Römer R4, Zou A7. Colloids Surf B Biointerfaces. 2016 Apr 13;145:95-103. doi: 10.1016/j.colsurfb.2016.04.027. [Epub ahead of print]
The hydrophilic drug Doxorubicin hydrochloride (DOX) paired with oleic acid (OA) was successfully incorporated into nanostructured lipid carriers (NLCs) by a high-pressure homogenization (HPH) method. Drug nanovehicles with proper physico-chemical characteristics (less than 200nm with narrow size distribution, spherical shape, layered internal organization, and negative electrical charge) were prepared and characterized by dynamic light scattering, zeta potential measurements, transmission electron microscopy, small-angle X-ray scattering and differential scanning calorimetry. The drug loading and entrapment efficiency of DOX-OA/NLCs were 4.09% and 97.80%, respectively. A pH-dependent DOX release from DOX-OA/NLCs, i.e., fast at pH 3.8 and 5.7 and sustained at pH 7.4, was obtained. A cytotoxicity assay showed that DOX-OA/NLCs had comparable cytotoxicity to pure DOX and were favorably taken up by HCT 116 cells. The intracellular distribution of DOX was also studied using a confocal laser scanning microscope.
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CAS 102120-99-0 rac-Rotigotine Hydrochloride

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