1.[Establishment and evaluation of a warfarin-dosing algorithm in Chinese Han population].
Li CB1, Dai DP2, Hu GX, Pu CW, Cao YP, Cai JP. Zhonghua Yi Xue Za Zhi. 2016 Mar 15;96(10):776-80. doi: 10.3760/cma.j.issn.0376-2491.2016.10.006.
OBJECTIVE: To develop and evaluate a warfarin-dosing algorithm method which can be used to guide the adjustment of warfarin maintenance dose in Chinese Han population.
2.Specific antidotes against direct oral anticoagulants: A comprehensive review of clinical trials data.
Tummala R1, Kavtaradze A1, Gupta A2, Ghosh RK3. Int J Cardiol. 2016 Mar 28;214:292-298. doi: 10.1016/j.ijcard.2016.03.056. [Epub ahead of print]
The Vitamin K antagonist warfarin was the only oral anticoagulant available for decades for the treatment of thrombosis and prevention of thromboembolism until Direct Oral Anticoagulants (DOACs); a group of new oral anticoagulants got approved in the last few years. Direct thrombin inhibitor: dabigatran and factor Xa inhibitors: apixaban, rivaroxaban, and edoxaban directly inhibit the coagulation cascade. DOACs have many advantages over warfarin. However, the biggest drawback of DOACs has been the lack of specific antidotes to reverse the anticoagulant effect in emergency situations. Activated charcoal, hemodialysis, and activated Prothrombin Complex Concentrate (PCC) were amongst the nonspecific agents used in a DOAC associated bleeding but with limited success. Idarucizumab, the first novel antidote against direct thrombin inhibitor dabigatran was approved by US FDA in October 2015. It comprehensively reversed dabigatran-induced anticoagulation in a phase I study.
3.Early postoperative haematomas in neurosurgery.
Nittby HR1, Maltese A2, Ståhl N2. Acta Neurochir (Wien). 2016 May;158(5):837-46. doi: 10.1007/s00701-016-2778-4. Epub 2016 Mar 28.
BACKGROUND: A postoperative haematoma can be a very serious complication following a neurosurgical procedure. Patients should be informed about the risks of such an event prior to surgery. From a practical point of view, it would be important to know when the patient is most likely to deteriorate and to require surgery because of a postoperative haematoma and when it might be safe to transfer the patient to the regular ward. The up-to-date studies regarding this topic are few.
4.[Determination of Warfarin Enantiomers in Human Plasma with HPLC-MS/MS].
Shen YC, Xiang J, Liang MZ, Yu Q, Nan F, Qin YP. Sichuan Da Xue Xue Bao Yi Xue Ban. 2016 Jan;47(1):106-10.
OBJECTIVE: To establish a high performance liquid chromatography-mass spectrometry/mass spectrometry (HPLC-MS/MS) method for determination of warfarin enantiomers in human plasma.