(R)-(+)-Tolterodine - CAS 124937-51-5
Catalog number:
124937-51-5
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H31NO
Molecular Weight:
325.49
COA:
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Targets:
mAChR
Description:
A muscarinic receptor antagonist. Used in the treatment of urinary incontinence.
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Purity:
>98%
Synonyms:
(+)-Tolterodine; (R)-Tolterodine; PNU-200583
MSDS:
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1.Mast cell activation and response to tolterodine in the rat urinary bladder in a chronic model of intravesical protamine sulfate and bacterial endotoxin-induced cystitis.
Choi BH1, Jin LH2, Kim KH3, Han JY4, Kang JH1, Yoon SM5, Park CS1, Lee T5. Mol Med Rep. 2014 Aug;10(2):670-6. doi: 10.3892/mmr.2014.2262. Epub 2014 May 22.
The aim of the present study was to use an animal model of interstitial cystitis (IC) in order to investigate the histology and function of the bladder, with a particular focus on mast cell degranulation and response to detrusor overactivity (DO) to tolterodine. A total of 18 female Sprague‑Dawley rats were used. In 12 rats, lipopolysaccharide (LPS) was intravesically instilled following the induction of IC by protamine sulfate (PS) and six rats were subjected to sham instillations. Following 1 month, cystometry was performed. The effects of tolterodine were tested in half of the animals with IC. All rats in the IC group demonstrated DO during the filling phase and no significant changes in the frequency or pressure compared with that following tolterodine injection were identified. Histological examination revealed a significant increase in the total number of infiltrated mast cells in IC rats compared with that in the sham rats (P<0.
2.Selective inhibitory effect of imidafenacin and 5-hydroxymethyl tolterodine on capsaicin sensitive C fibers of the primary bladder mechanosensitive afferent nerves in the rat.
Aizawa N1, Ito H1, Sugiyama R1, Fujimura T1, Suzuki M1, Fukuhara H1, Homma Y1, Igawa Y2. J Urol. 2015 Apr;193(4):1423-32. doi: 10.1016/j.juro.2014.09.005. Epub 2014 Sep 16.
PURPOSE: Imidafenacin and fesoterodine are used to treat overactive bladder. Imidafenacin, fesoterodine and its active metabolite 5-hydroxymethyl tolterodine are muscarinic receptor antagonists. It is believed that these agents act on afferent nerves in addition to smooth muscle. We investigated the effects of imidafenacin and 5-hydroxymethyl tolterodine on single unit afferent activity of mechanosensitive capsaicin sensitive and insensitive primary bladder afferent nerve fibers in rats.
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CAS 124937-51-5 (R)-(+)-Tolterodine

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