|Description||(R)-(-)-Apomorphine hydrochloride is the hydrochloride salt of apomorphine, which is a prototypical non-selective dopamine D2 agonist. It exhibits pKi values of 6.43, 7.08, 7.59, 8.36, and 7.83 for human recombinant D1, D2L, D3, D4, and D5 receptors, respectively. It produces biphasic effects on locomotor activity and shows neuroprotective actions following systemic administration in vivo. It has the potential for the treatment of Parkinson's disease. It also promotes intraneuronal amyloid-β (Aβ) degradation and improves memory function in an Alzheimer's disease model. It may improve brain insulin resistance.|
|Purity||≥99% by HPLC|
|Synonyms||5,6,6aR,7-tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol, monohydrochloride; (6aR)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol Hydrochloride; (R)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol Hydrochloride; 6aβ-Aporphine-10,11-diol Hydrochloride; (-)-Apomorphine Hydrochloride; Apomorphine Hydrochloride; Uprima|
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