(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid - CAS 103733-65-9
Catalog number: 103733-65-9
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C10H11NO2
Molecular Weight:
177.2
COA:
Inquire
Targets:
Others
Description:
(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid is a constrained Phe analogue which can fold into a beta-bend and a helical structure, and to adopt a preferred side-chain disposition in the peptide.
Purity:
>98%
MSDS:
Inquire
InChIKey:
BWKMGYQJPOAASG-SECBINFHSA-N
InChI:
InChI=1S/C10H11NO2/c12-10(13)9-5-7-3-1-2-4-8(7)6-11-9/h1-4,9,11H,5-6H2,(H,12,13)/t9-/m1/s1
Canonical SMILES:
C1C(NCC2=CC=CC=C21)C(=O)O
1.Synthesis and biological activity of oxytocin analogues containing conformationally-restricted residues in position 7.
Fragiadaki M;Magafa V;Borovicková L;Slaninová J;Cordopatis P Eur J Med Chem. 2007 Jun;42(6):799-806. Epub 2007 Jan 10.
We report the solid-phase synthesis and some pharmacological properties of twenty oxytocin (OT) analogues. Basic modifications at position 7 (introduction of alpha-aminoisobutyric acid [Aib], L- or D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid [L/D-Tic], L-alpha-t-butylglycine [Gly(Bu(t))] and pipecolic acid [Pip]) were combined with D-Tyr(Et)(2), L/D-(pEt)Phe(2), D-Tic(2), and Mpa(1) modifications and their various combinations in a total of 14 analogues. Additionally, two analogues having one more modification in position 3, i.e. Gly(Bu(t)), and three analogues having glycine in position 9 substituted by d-Tic or Aib, were prepared. The analogues were tested for rat uterotonic activity in vitro, in the rat pressor assay and for binding affinity to human OT receptor. The analogue having the highest antioxytocic activity was [Mpa(1), D-Tyr(Et)(2), D-Tic(7), Aib(9)]OT having pA(2)=8.31+/-0.19; this analogue was also selective.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 2083627-02-3 EED-226

EED-226
(CAS: 2083627-02-3)

EED-226 is a novel allosteric Polycomb repressive complex 2 (PRC2) inhibitor (IC50 = 23.4 nM when the substrate is H3K27me0 peptide and IC50 = 53.5 nM when the ...

CAS 1370290-58-6 Spexin

Spexin
(CAS: 1370290-58-6)

Spexin is an endogenous satiety-inducing peptide and a potent galanin receptor 2/3 (GAL2/GAL3) agonist (EC50 = 45.7 and 112.2 nM, respectively), displaying no s...

GSK172981
(CAS: 1133705-99-3)

This molecular is a novel non-peptide tachykinin NK3 receptor antagonist and it has a very high affinity for native guinea pig (pK(i) value 7.8) tachykinin NK(3...

CAS 12583-68-5 Parathyroid hormone (1-34) (bovine)

Parathyroid hormone (1-34) (bovine)
(CAS: 12583-68-5)

Parathyroid hormone (1-34) (bovine) is a parathyroid hormone (PTH) receptor agonist. It increases calcium and inorganic phosphate levels in the serum of young r...

CAS 890819-86-0 ML 349

ML 349
(CAS: 890819-86-0)

ML 349 is a lysophospholipase 2 inhibitor with IC50 value of 144 nM.

CAS 10309-37-2 Bakuchiol

Bakuchiol
(CAS: 10309-37-2)

Bakuchiol is a phytoestrogen isolated from the seeds of Psoralea corylifolia L with an anti-tumor effects.

CAS 169105-89-9 Isofagomine

Isofagomine
(CAS: 169105-89-9)

Isofagomine, an imino pyranose compound, has been found to be a glucosylceramidase stimulant and could exhibit activity in Gaucher's disease.

REP 3123 dihydrochloride
(CAS: 1013915-99-5)

REP 3123 dihydrochloride is a selective inhibitor of methionyl-tRNA synthetase (MetRS) used as an antibiotic for the treatment of Clostridium difficile infectio...

Chemical Structure

CAS 103733-65-9 (R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid

Quick Inquiry

Verification code

Featured Items