(-)-Quinpirole hydrochloride - CAS 85798-08-9
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
Dopamine Receptor
(-)-Quinpirole hydrochloride is a selective dopamine D2 receptor agonist, with high affinity for the D2 and D3 dopamine receptor subtypes (Ki values are 4.8, ~24, ~30 and 1900 nM at D2, D3, D4 and D1 receptors respectively).
≥98% by HPLC
(4aR-trans)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline hydrochloride; (-)-Quinpirole hydrochloride; (-)Quinpirole hydrochloride; (-)-Quinpirole HCl; (-)Quinpirole HCl; (-) Quinpirole HCl; LY-171555; LY 171555; LY171555
Store in a cool and dry place (or refer to the Certificate of Analysis).
Canonical SMILES:
1.SKF 38393 potentiates yawning induced by LY 171555: further evidence against the autoreceptor hypothesis of yawning.
Spina L;Longoni R;Mulas A;Di Chiara G Psychopharmacology (Berl). 1989;98(4):567-8.
The effect of concurrent D-1 receptor stimulation by SKF 38393 on the expression of yawning elicited by D-2 receptor stimulation with LY 171555 was studied in the rat. A low dose of SKF 38393 (2.5 mg/kg SC), while failed to elicit yawning, potentiated the effectiveness of LY 171555 in eliciting yawning at all the doses tested (12.5, 25 and 50 micrograms/kg SC) and this effect was abolished by SCH 23390 (0.012 mg/kg SC). The results indicate that in analogy with typical post-synaptic dopaminergic effects (hypermotility-stereotypy), yawning elicited by a D-2 agonist is facilitated by concurrent stimulation of D-1 receptors and therefore is consistent with previous evidence that yawning in response to a D-2 agonist is not mediated by autoreceptors.
2.Yawning is elicited by D2 dopamine agonists but is blocked by the D1 antagonist, SCH 23390.
Serra G;Collu M;Gessa GL Psychopharmacology (Berl). 1987;91(3):330-3.
The subtype of dopamine (DA) receptors mediating the yawning response to DA agonists was determined in rats. Yawning was elicited both by the mixed D1-D2 agonist apomorphine and by the specific D2 agonist LY 171555, but not by the selective D1 agonist SKF 38393. Both apomorphine- and LY 171555-induced yawning were antagonized not only by the selective D2 antagonist sulpiride but, unexpectedly, also by the selective D1 antagonist SCH 23390. The results suggest that DA receptors mediating the yawning response are of the D2 type, and that these receptors are connected with D1 receptors in such a way that the blockade of the latter results in the functional inactivation of the former.
3.Potential therapeutic use of the selective dopamine D1 receptor agonist, A-86929: an acute study in parkinsonian levodopa-primed monkeys.
Grondin R;Bédard PJ;Britton DR;Shiosaki K Neurology. 1997 Aug;49(2):421-6.
The clinical utility of dopamine (DA) D1 receptor agonists in the treatment of Parkinson's disease (PD) is still unclear. The therapeutic use of selective DA D1 receptor agonists such as SKF-82958 (6-chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzaze pine hydrobromide) and A-77636 ([1R, 3S] 3-[1'-admantyl]-1-aminomethyl-3,4-dihydro-5,6-dihydroxy-1H-2-benzo pyran hydrochloride) seems limited because of their duration of action, which is too short for SKF-82958 (< 1 hr) and too long for A-77636 (> 20 hr, leading to behavioral tolerance). We therefore conducted the present acute dose-response study in four 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-exposed cynomolgus monkeys primed to exhibit levodopa-induced dyskinesias to evaluate the locomotor and dyskinetic effects on challenge with four doses (from 0.03 to 1.0 mg/kg) of A-86929 ([-]-[5aR,11bS]-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-+ ++azacyclopent-1- ena[c]phenathrene-9-10-diol), a selective and full DA D1-like receptor agonist with an intermediate duration of action. Levodopa and the DA D2-like receptor agonist, LY-171555 ([4aR-trans]-4,4a,5,6,7,8,8a,9-o-dihydro-5n-propyl-2H-pyrazo lo-3-4-quinoline hydrochloride) were also used for comparison.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Dopamine Receptor Products

CAS 52-86-8 Haloperidol

(CAS: 52-86-8)

Haloperidol (Haldol) is an antipsychotic and butyrophenone.

CAS 26615-21-4 Zotepine

(CAS: 26615-21-4)

Zotepine is a 5-HT2A receptor and dopamine D2 receptor antagonist (Ki = 0.69 and 2.3 nM, respectively) used as an atypical antipsychotic for the treatment of sc...

CAS 67227-57-0 Fenoldopam Mesylate

Fenoldopam Mesylate
(CAS: 67227-57-0)

Fenoldopam is a selective D1 receptor partial agonist, binds to α2-adrenoceptors, increasing renal blood flow used as an antihypertensive agent.

CAS 71787-90-1 PPHT hydrochloride

PPHT hydrochloride
(CAS: 71787-90-1)

PPHT hydrochloride is a potent and selective D2 agonist.

CAS 65273-67-8 N,N-dibutyldopamine hydrobromide

N,N-dibutyldopamine hydrobromide
(CAS: 65273-67-8)

A dopamine receptor agonist.

CAS 62421-17-4 TL 232 hydrobromide

TL 232 hydrobromide
(CAS: 62421-17-4)

TL 232 hydrobromide is a dopamine receptor agonist.

CAS 913611-97-9 Brexpiprazole

(CAS: 913611-97-9)

Brexpiprazole, a novel atypical antipsychotic drug, is a D2 dopamine partial agonist called serotonin-dopamine activity modulator (SDAM). It is approved for the...

CAS 2804-05-9 Azaperol

(CAS: 2804-05-9)

Azaperol acts as a dopamine antagonist and also has antihistaminic and anticholinergic properties. Azaperol is commonly used as a butyrophenone neuroleptic drug...

Chemical Structure

CAS 85798-08-9 (-)-Quinpirole hydrochloride

Quick Inquiry

Verification code

Featured Items