Quercetin - CAS 117-39-5
Catalog number: B0084-462909
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H10O7
Molecular Weight:
302.238
COA:
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Targets:
PI3K
Description:
Quercetin is a flavonoid found in galangal and is used as an antitumor agent that induces apoptosis of cancer cells. It acts as a PI 3-kinase and protein kinase C (PKC) inhibitor, and inhibits tyrosine protein kinase, phospholipase A2, phosphodiesterases and mitochondrial ATPase. It also suppresses Ca2+ and K+ channels, and activates GPR30.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-462909 250 g $288 In stock
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Brife Description:
PI3K inhibitor
Purity:
≥ 98%
Synonyms:
Sophoretin; Meletin; Xanthaurine; Quercetine; 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one
MSDS:
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Application:
antitumor agent
InChIKey:
REFJWTPEDVJJIY-UHFFFAOYSA-N
InChI:
InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
Canonical SMILES:
C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O
1.Increase of rutin antioxidant activity by generating Maillard reaction products with lysine.
Zhang R1, Zhang BL2, He T1, Yi T1, Yang JP1, He B1. Bioorg Med Chem Lett. 2016 Apr 5. pii: S0960-894X(16)30369-9. doi: 10.1016/j.bmcl.2016.04.008. [Epub ahead of print]
Rutin exists in medicinal herbs, fruits, vegetables, and a number of plant-derived sources. Dietary sources containing rutin are considered beneficial because of their potential protective roles in multiple diseases related to oxidative stresses. In the present study, the change and antioxidation activity of rutin in Maillard reaction with lysine through a heating process were investigated. There is release of glucose and rhamnose that interact with lysine to give Maillard reaction products (MRPs), while rutin is converted to less-polar quercetin and a small quantity of isoquercitrin. Because of their high cell-membrane permeability, the rutin-lysine MRPs increase the free radical-scavenging activity in HepG2 cells, showing cellular antioxidant activity against Cu2+-induced oxidative stress higher than that of rutin. Furthermore, the MRPs significantly increased the Cu/Zn SOD (superoxide dismutase) activity and Cu/Zn SOD gene expression of HepG2 cells, consequently enhancing antioxidation activity.
2.Study of the interaction of flavonoids with 3-mercaptopropionic acid modified CdTe quantum dots mediated by cetyltrimethyl ammonium bromide in aqueous medium.
Aucelio RQ1, Carvalho JM1, Real JT1, Maqueira-Espinosa L1, Pérez-Gramatges A1, da Silva AR2. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Apr 12. pii: S1386-1425(16)30196-2. doi: 10.1016/j.saa.2016.04.021. [Epub ahead of print]
Flavonoids are polyphenols that help the maintenance of health, aiding the prevention of diseases. In this work, CdTe QDs coated with 3-mercaptopropionic acid (3MPA), with an average size of 2.7nm, were used as photoluminescence probe for flavonoids in different conditions. The interaction between 14 flavonoids and QDs was evaluated in aqueous dispersions in the absence and in the presence of cetyltrimethylammonium bromide (CTAB). To establish a relationship between photoluminescence quenching and the concentration of flavonoids, the Stern-Volmer model was used. In the absence of CTAB, the linear ranges for quercetin, morin and rutin were from 5.0×10-6molL-1 to 6.0×10-5molL-1 and from 1.0×10-5molL-1 to 6.0×10-4molL-1 for kaempferol. The sensibility of the Stern-Volmer curves (Ks) indicated that quercetin interacts more strongly with the probe: Ks quercetin>Ks kaempferol>Ks rutin>Ks morin. The conjugation extension in the 3 rings, and the acidic hydroxyl groups (positions 3'and 4') in the B-ring enhanced the interaction with 3MPA-CdTe QDs.
3.Quercetin stabilizes apolipoprotein E and reduces brain Aβ levels in amyloid model mice.
Zhang X1, Hu J1, Zhong L1, Wang N1, Yang L1, Liu CC1, Li H1, Wang X1, Zhou Y1, Zhang Y1, Xu H1, Bu G2, Zhuang J3. Neuropharmacology. 2016 Apr 22. pii: S0028-3908(16)30172-1. doi: 10.1016/j.neuropharm.2016.04.032. [Epub ahead of print]
Apolipoprotein E (apoE) is a major cholesterol carrier that regulates lipid homeostasis by mediating lipid transport from one tissue or cell type to another. In the central neural system (CNS), apoE is mainly produced by astrocytes, and transports cholesterol to neurons via apoE receptors, which are members of the low-density lipoprotein receptor family. The APOEε4 gene is a strong genetic risk factor for late-onset sporadic Alzheimer's disease (AD), likely through its strong effect on the accumulation of amyloid-β (Aβ) peptide. ApoE protein levels in cerebrospinal fluid (CSF) and plasma are reduced in APOEε4 carriers and in patients with AD. Furthermore, altered cholesterol levels are also associated with the risk of AD. Aβ accumulation, oligomerization and deposition in the brain are central to the pathogenesis of AD. Mounting evidence demonstrates that apoE and apoE receptors play important roles in these processes. Astrocyte-derived apoE is pivotal for cerebral cholesterol metabolism and clearance of Aβ.
4.Anti-inflammatory Activity of Berry Fruits in Mice Model of Inflammation is Based on Oxidative Stress Modulation.
Nardi GM1, Farias Januario AG1, Freire CG2, Megiolaro F2, Schneider K2, Perazzoli MR2, Do Nascimento SR1, Gon AC3, Mariano LN3, Wagner G4, Niero R3, Locatelli C2. Pharmacognosy Res. 2016 Mar;8(Suppl 1):S42-9. doi: 10.4103/0974-8490.178642.
BACKGROUND: Many fruits have been used as nutraceuticals because the presence of bioactive molecules that play biological activities.
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CAS 117-39-5 Quercetin

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