Qingyangshengenin - CAS 84745-94-8
Catalog number: 84745-94-8
Not Intended for Therapeutic Use. For research use only.
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Qingyangshengenin isolated from the roots of Cynanchum otophyllum.
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1.Two new steroidal glycosides from Cynanchum otophyllum Schneid.
Yang XX;Bao YR;Wang LF;Wang S;Bao LN;Guan YP;Meng XS J Asian Nat Prod Res. 2015;17(3):285-8. doi: 10.1080/10286020.2014.956308. Epub 2014 Oct 7.
Two new C21 steroidal glycosides were isolated from Cynanchum otophyllum Schneid. Their structures were elucidated as qinyangshengenin-3-O-β-d-digitoxopyranoside (1) and rostratamine-3-O-β-d-cymaropyranosyl-(1 → 4)-β-d-digitoxopyranoside (2) on the basis of chemical and spectroscopic methods, including 1D and 2D NMR experiments.
2.Chemical constituents of Arisaema franchetianum tubers.
Su Y;Xu JJ;Bi JL;Wang YH;Hu GW;Yang J;Yin GF;Long CL J Asian Nat Prod Res. 2013;15(1):71-7. doi: 10.1080/10286020.2012.723202. Epub 2012 Oct 29.
A novel pyrrolidine alkaloid, (2R*,3S*,5S*)-N,2-dimethyl-3-hydroxy-5-(10-phenyldecyl)pyrrolidine (1), and 17 known compounds were isolated from Arisaema franchetianum Engl. (Araceae) tubers. The 17 compounds were bergenin (2), emodin (3), caffeic acid (4), nobiletin (5), 3-O-β-d-galactopyranosyl-hederagenin 28-O-β-d-xylopyranosyl(1 → 6)-β-d-galactopyranosyl ester (6), coniferin (7), qingyangshengenin (8), methylconiferin (9), syringaresinol 4'-O-β-d-glucopyranoside (10), gagaminine (11), perlolyrine (12), (S)-1-(1'-hydroxyethyl)-β-carboline (13), 1-(β-carboline-1-yl)-3,4,5-trihydroxy-1-pentanone (14), 1-methoxycarbonyl-β-carboline (15), indolo[2,3-α]carbazole (16), 4-hydroxycinnamic acid methyl ester (17), and methyl 4-[2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-1-(hydroxymethyl)ethyl] ferulate (18). The inhibitory activities of compound 1 and its N-methyl derivative (1a) against porcine respiratory and reproductive syndrome virus (PRRSV), human leukemic K562 cells, and human breast cancer MCF-7 cells were evaluated. Compounds 1 [50% inhibited concentration (IC(50)) = 12.5 ± 0.6 μM] and 1a (IC(50) = 15.7 ± 0.9 μM) were cytotoxic against K562 cells. Compound 1a also had a weak effect on PRRSV with an IC(50) value of 31.
3.C21 steroidal glycosides from Cynanchum wallichii Wight.
Chen G;Xu N;Pei YH J Asian Nat Prod Res. 2009;11(2):177-82. doi: 10.1080/10286020802619017.
Three new C21 steroidal glycosides, characterized with rostratamine and qinyangshengenin as aglycone moiety and 2,6-dideoxy-pyranoses as component sugars, have been isolated from the roots of Cynanchum wallichii Wight. The structures of the three new C21 steroidal glycosides were elucidated as rostratamine-3-O-beta-D-oleandropyranosyl-(1 --> 4)-beta-d-cymaropyranosyl-(1 --> 4)-beta-D-cymaropyranoside, qinyangshengenin-3-O-beta-D-cymaropyranosyl-(1 --> 4)-beta-D-digitoxo-pyranoside, and qinyangshengenin-3-O-beta-D-oleandropyranosyl-(1 --> 4)-beta-D-cymaropyranosyl-(1 --> 4)-beta-D-digitoxopyranoside.
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CAS 84745-94-8 Qingyangshengenin

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