Pyrvinium pamoate - CAS 3546-41-6
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C26H28N3.1/2C23H14O6
Molecular Weight:
575.7
COA:
Inquire
Targets:
Androgen Receptor | Wnt
Description:
Pyrvinium pamoate, a nonabsorbed anthelmintic drug, is a potent androgen receptor inhibitor and a selective WNT pathway inhibitor. Pyrvinium pamoate is a potential drug candidate for the treatment of cryptosporidiosis in both immunocompetent and immunocompromised individuals.
Brife Description:
A potent androgen receptor inhibitor and a selective WNT pathway inhibitor
Synonyms:
VPC-14337; VPC 14337; VPC14337; 6-(Dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methyl-4,4′-methylenebis[3-hydroxy-2-naphthalenecarboxylate] (2:1)-quinolinium, Alnoxin, Altolat, NSC 223622, PP, Pamovin, Vermitibier, Vipyrvinium embonate
Solubility:
DMSO: ≥ 24 mg/mL
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Melting Point:
210-215 ℃
InChIKey:
OOPDAHSJBRZRPH-UHFFFAOYSA-L
InChI:
InChI=1S/2C26H28N3.C23H16O6/c2*1-19-17-21(20(2)29(19)24-9-7-6-8-10-24)11-13-23-14-12-22-18-25(27(3)4)15-16-26(22)28(23)5;24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29/h2*6-18H,1-5H3;1-10,24-25H,11H2,(H,26,27)(H,28,29)/q2*+1;/p-2
Canonical SMILES:
CC1=CC(=C(N1C2=CC=CC=C2)C)C=CC3=[N+](C4=C(C=C3)C=C(C=C4)N(C)C)C.CC1=CC(=C(N1C2=CC=CC=C2)C)C=CC3=[N+](C4=C(C=C3)C=C(C=C4)N(C)C)C.C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)[O-])[O-])C(=O)O
1.In vitro activity of pyrvinium pamoate against Entamoeba histolytica and Giardia intestinalis using radiolabelled thymidine incorporation and an SYBR Green I-based fluorescence assay.
Downey AS;Graczyk TK;Sullivan DJ J Antimicrob Chemother. 2009 Oct;64(4):751-4. doi: 10.1093/jac/dkp296. Epub 2009 Aug 18.
OBJECTIVES: ;To assess the in vitro activity of the FDA-approved antihelminthic drug pyrvinium pamoate against Entamoeba histolytica and Giardia intestinalis.;METHODS: ;A head-to-head comparison of a standard radiolabelled thymidine incorporation assay and the SYBR Green I-based fluorescence assay for determination of in vitro inhibition by pyrvinium and metronidazole was performed.;RESULTS: ;The 50% inhibitory concentration (IC(50)) for treatment of E. histolytica with pyrvinium was 4-5 microM for both assays compared with 1-2 microM for metronidazole. For pyrvinium treatment of G. intestinalis, an IC(50) of approximately 12 microM was determined by the radiolabelled thymidine assay alone, with maximum inhibition around 60%. In contrast, the IC(50) for metronidazole treatment using this assay was approximately 2 microM.;CONCLUSIONS: ;Pyrvinium is a potential gut lumen agent for treatment of intestinal amoebiasis, but possibly not for giardiasis. SYBR Green I is an alternative screening method for E. histolytica, but not G. intestinalis.
2.[Strongyloidosis in Canavese: 4 cases seen at the 'Ospedale di Ivrea-Castellamonte. Epidemiological and clinical considerations].
Ronchetto F;Pistono PG;Guasco C G Batteriol Virol Immunol. 1990 Jan-Dec;83(1-12):42-52.
From May 1988 to September 1990 the microbiology laboratory of the Ivrea-Castellamonte Hospital (Province of Turin) carried out 1464 coproparasitological investigations. 0.5% of the samples, coming from 5 patients, proved to be Strongyloides stercoralis positive. 4 cases were diagnosed in recovery conditions, and on these we carried out a retrospective study (taking into consideration some epidemiological and clinical aspects). The average age of these patients, three men and one woman, was 70.5; all native of the Canavese and resident in agricultural zones; two farmers still working, a worker and a retired worker. All of them presented one or more associated pathologies and/or a tendency to parasitosis. The clinical picture was characterized by abdominal pain, present in three cases, while diarrhoea was observed in only one case; a slight temperature in two, a high temperature in one; nettle-rash manifestations in one case and breathing symptomatology in two. In two cases there appeared abdominal relaxation (meteorism) and in one of these there was a serious paralytic ileus. Eosinophilia was present in all the patients, even if at different levels (from 5.9% to 20%). The treatment was carried out with different drugs: mebendazole in two cases, thiabendazole in one and "pyrvinium pamoate" in another.
3.Study of the laxative properties of the disodium salt of the sulfuric diester of 3,3-bis-(4-hydroxyphenyl)-7-methyl-2-indolinone (DAN-603 in the rat.
Moretó M;Goñalons E;Giráldez A;Torralba A Eur J Pharmacol. 1976 Mar;36(1):223-6.
The influence of DAN-603 (disodium salt of sulphuric diester of 3,3-bis-(4-hydroxyphenyl)-7-methyl-2-indolinone) on the propulsive motility of the rat digestive tract was studied by means of indicators (charcoal and pyrvinium pamoate) and radioactive tracers (133BaSO4). The results showed that DAN-603 increases selectively the colon motility without modifying the speed of gastric, intestinal (small intestine) and caecal emptying.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Androgen Receptor Products


CAS 1467013-03-3 Adavivint

Adavivint
(CAS: 1467013-03-3)

Adavivint is a Wnt pathway inhibitor.

CAS 956104-40-8 Apalutamide

Apalutamide
(CAS: 956104-40-8)

Apalutamide is a potent and competitive androgen receptor (AR) antagonist with potential antineoplastic activity. It binds to AR in target tissues thereby preve...

CAS 915087-33-1 Enzalutamide

Enzalutamide
(CAS: 915087-33-1)

Enzalutamide is an androgen-receptor (AR) antagonist with IC50 of 36 nM. It inhibits the activity of prostate cancer cell Ars, which over expressed in prostate ...

CAS 52-01-7 Spironolactone

Spironolactone
(CAS: 52-01-7)

Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM.

CAS 442644-28-2 JW 67

JW 67
(CAS: 442644-28-2)

JW 67 has been found to be a new antagonist of canonical Wnt signaling and exhibit activities in restraining growth and downregulated Wnt target genes in human ...

CAS 838818-26-1 WIKI4

WIKI4
(CAS: 838818-26-1)

WIKI4 is a novel inhibitor of tankyrase and Wnt/ß-catenin signaling. WIKI4 inhibits expression of ß-catenin target genes and cellular responses to Wnt/ß-catenin...

CAS 853220-52-7 BML-284

BML-284
(CAS: 853220-52-7)

BML-284 is potent selective, and cell-permeable Wnt signaling activator that does not inhibit GSK-3β (IC50 > 60 µM). It appears to mimic the effects of a Wnt li...

CAS 90357-06-5 Bicalutamide

Bicalutamide
(CAS: 90357-06-5)

Bicalutamide is a non-steroidal androgen receptor (AR) antagonist with IC50 of 0.16 μM.

Chemical Structure

CAS 3546-41-6 Pyrvinium pamoate

Quick Inquiry

Verification code

Featured Items