Pyrrolidinedithiocarbamate Ammonium - CAS 5108-96-3
Catalog number: 5108-96-3
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C5H9NS2.NH3
Molecular Weight:
164.29
COA:
Inquire
Targets:
NF-κB
Description:
Pyrrolidinedithiocarbamate ammonium is a selective NF-κB inhibitor, inducing apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells.
Purity:
≥98%
Appearance:
Pale yellow solid
Synonyms:
1-Pyrrolidinecarbodithioic Acid, Ammonium Salt; Ammonium 1-Pyrrolidinecarbodithioat;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
Induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells.
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
Melting Point:
150-155 ºC
Density:
1.264 g/cm3
InChIKey:
MDDIUTVUBYEEEM-UHFFFAOYSA-N
InChI:
1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3
Canonical SMILES:
C1CCN(C1)C(=S)[S-].[NH4+]
1.Multi-element analysis of saline matrices by inductively coupled plasma mass spectrometry following on-line preconcentration using a knotted reactor.
Silva FA1, da Silveira CL, Miekeley N, Kuechler IL. Anal Sci. 2004 Sep;20(9):1295-9.
A versatile preconcentration system for trace element determination by ICPMS was developed. It is composed of a commercial flow injection analysis system (FIAS) retrofitted with a home-made control unit containing three solenoid valves and working concomitantly with the FIAS, permitting selection and segmentation of sample, reagent, washing solution and elution flow. The knotted reactor used had a length of 200 cm and was made from 0.05 cm i.d. PTFE tubing. The method applies ammonium 1-pyrrolidinedithiocarbamate (APDC) as complexant, allowing the preconcentration and quantitative multi-element determination of Cu, Ni, V, Co, Nb, Mo, In, Sb and Bi. Ethanol and 4-methyl-2-pentanone were tested as eluents. Recovery tests using complex matrices and spike concentrations of 200 ng L(-1) showed typical values in the range of 90% to 110%. Relative standard deviations were < 7% for elution with ethanol and < 5% with methyl isobutyl ketone.
2.Determination of platinum in serum and ultrafiltrate by flameless atomic absorption spectrophotometry.
Hull DA, Muhammad N, Lanese JG, Reich SD, Finkelstein TT, Fandrich S. J Pharm Sci. 1981 May;70(5):500-2.
A graphite furnace atomic absorption spectrophotometric assay, capable of accurately determining nanogram amounts of platinum in serum and ultrafiltrate, was developed. A sample serum or ultrafiltrate was acidified with nitric acid and heated to destroy the protein-platinum bond. A measured excess of ammonium 1-pyrrolidinedithiocarbamate was added, and the platinum complex was extracted into isopropylacetone. The extract was injected into the graphite furnace. The sample was dried, charred, and atomized using optimal conditions. The resulting absorbance was used to determine the platinum content.
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CAS 5108-96-3 Pyrrolidinedithiocarbamate Ammonium

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